Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Clinical and Experimental Hypertension : CHE
Michihiro SatohYutaka Imai

Abstract

We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

References

Jan 1, 1992·European Journal of Clinical Pharmacology·T MengdenW Vetter
Apr 26, 2003·Journal of Hypertension·Eoin O'BrienUNKNOWN European Society of Hypertension Working Group on Blood Pressure Monitoring
Sep 25, 2007·Blood Pressure Monitoring·Taku ObaraUNKNOWN J-HOME study group
May 30, 2009·Stroke; a Journal of Cerebral Circulation·Ryusuke InoueYutaka Imai

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Citations

Oct 12, 2014·The Science of the Total Environment·Thuan-Quoc ThachChit-Ming Wong
Jan 18, 2014·American Journal of Public Health·Donald L ChiJohn P Ney

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