journal cover

Hypotensive and vasodilator actions of SK&F 24260, a new dihydropyridine derivative

British Journal of Pharmacology

Nov 1, 1974

R FieldenE M Taylor

Abstract

1 The blood pressure of conscious normotensive, Goldblatt-hypertensive and genetic-hypertensive rats and normotensive dogs was lowered by SK&F 24260 (1,4-dihydro-2,6-dimethyl-4-(2-trifluormethylphenyl)-3,5-pyridinedicarboxylic acid diethyl ester).2 Tachycardia always accompanied the hyp...read more

Mentioned in this Paper

3,5-pyridinedicarboxylic acid
Vasodilator [EPC]
Pyridines
Familial Hypertension
SK&F 24260
Total Peripheral Resistance
Papaverine
Hypertension, Renovascular
Organic Chemicals
Blood Vessel
Paper Details
References
  • References9
  • Citations12
  • References9
  • Citations12
12

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Hypotensive and vasodilator actions of SK&F 24260, a new dihydropyridine derivative

British Journal of Pharmacology

Nov 1, 1974

R FieldenE M Taylor

PMID: 4458842

DOI: 10.1111/j.1476-5381.1974.tb08599.x

Abstract

1 The blood pressure of conscious normotensive, Goldblatt-hypertensive and genetic-hypertensive rats and normotensive dogs was lowered by SK&F 24260 (1,4-dihydro-2,6-dimethyl-4-(2-trifluormethylphenyl)-3,5-pyridinedicarboxylic acid diethyl ester).2 Tachycardia always accompanied the hyp...read more

Mentioned in this Paper

3,5-pyridinedicarboxylic acid
Vasodilator [EPC]
Pyridines
Familial Hypertension
SK&F 24260
Total Peripheral Resistance
Papaverine
Hypertension, Renovascular
Organic Chemicals
Blood Vessel

Similar Papers Found In These Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Analytical Biochemistry

Iron contamination in adenosine triphosphate: a warning

Analytical BiochemistrySeptember 1, 1992
R E McCarty
The Journal of Pharmacy and Pharmacology

Dihydropyridines with potent hypotensive activity prepared by the Hantzsch reaction

The Journal of Pharmacy and PharmacologyNovember 1, 1972
B LoevR E Tedeschi
Paper Details
References
  • References9
  • Citations12
  • References9
  • Citations12
12
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