Hypotensive effect of clonidine during sodium depletion in the rat.

Circulation Research
D T Pals

Abstract

Clonidine was nonhypotensive in conscious unrestrained rats maintained on a normal sodium intake. In contradistinction, clonidine caused a dose-related hypotension in conscious unrestrained rats subjected to sodium depletion via furosemide. The plasma renin activity of normal and sodium-depleted rats was reduced after the administration of clonidine (100 mug/kg, iv) by 22.8% and 34.4%, respectively. Intravenous infusion of an angiotensin II antagonist, 1-Sar-8-Ala-angiotensin II, caused a significant reduction of arterial blood pressure in sodium-depleted rats but not in normal rats. Similarly, bilateral nephrectomy reduced arterial blood pressure and completely abolished the hypotensive effect of clonidine in sodium-depleted rats. Subcutaneous administration of chlorisondamine caused a significantly greater reduction of arterial blood pressure in sodium-depleted rats than it did in normal rats. Treatment of normal and sodium-depleted rats with 6-hydroxydopamine reduced the arterial blood pressure of both groups to approximately 85 mm Hg and completely abolished the hypotensive effect of clonidine in the sodium-depleted rats. The data presented in this paper are consistent with the conclusion that clonidine acts at some site in...Continue Reading

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Apr 1, 1978·Journal of Clinical Pharmacology·A P Niarchos
Nov 23, 1976·The American Journal of Cardiology·M A WeberJ H Laragh
Nov 1, 1977·The Journal of Pharmacy and Pharmacology·P Zandberg, W De Jong
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May 21, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·James O FajemiroyeElson A Costa

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