PMID: 8941862Oct 1, 1996Paper

Hypotensive effect of crude root extract of Solanum sisymbriifolium (Solanaceae) in normo- and hypertensive rats

Journal of Ethnopharmacology
D A IbarrolaE A Ferro

Abstract

The hypotensive effect of the crude hydroalcoholic extract from root of Solanum sisymbriifolium Lam. (Solanaceae) was investigated both in normotensive and hypertensive rats. The intravenous administration of the extract (50 and 100 mg/kg) produced a significant decrease in blood pressure in anaesthetized hypertensive (adrenal regeneration hypertension + deoxycorticosterone acetate (ARH + DOCA)) rats. Oral administration of the extract (10, 50, 100 and 250 mg/kg) also produced a dose-dependent hypotensive effect in conscious hypertensive animals. In anaesthetized normotensive rats, the extract (50 and 100 mg/kg, i.v.) also induced hypotension in a dose-dependent manner. Lastly, no significant effect on blood pressure was produced by the extract when administered orally (10, 50, 100, 250, 500 and 1000 mg/kg) to conscious normotensive rats.

References

Jan 1, 1975·International Urology and Nephrology·E Tarján, A Fekete
Jan 1, 1991·Hypertension·D F Bohr, A F Dominiczak

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Citations

Jun 6, 2000·Journal of Ethnopharmacology·D A lbarrolaE A Ferro
Nov 19, 2011·Pharmacognosy Reviews·Nahida Tabassum, Feroz Ahmad
Apr 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L O SimõesD F Silva
Mar 26, 2016·Frontiers in Pharmacology·M Akhtar AnwarAli H Eid
Mar 11, 2015·Fundamental & Clinical Pharmacology·José L R MartinsElson A Costa
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Valdir Cechinel FilhoAngela Malheiros
Jul 2, 2005·Fitoterapia·E A FerroA G Ravelo
Nov 30, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco J Luna-VázquezMiguel Ángel Zavala-Sánchez
May 20, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G G FigueiredoV H Aquino

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