Hypotensive Snake Venom Components-A Mini-Review

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Orsolya PéterfiLászló Bába

Abstract

Hypertension is considered a major public health issue due to its high prevalence and subsequent risk of cardiovascular and kidney diseases. Thus, the search for new antihypertensive compounds remains of great interest. Snake venoms provide an abundant source of lead molecules that affect the cardiovascular system, which makes them prominent from a pharmaceutical perspective. Such snake venom components include bradykinin potentiating peptides (proline-rich oligopeptides), natriuretic peptides, phospholipases A2, serine-proteases and vascular endothelial growth factors. Some heparin binding hypotensive factors, three-finger toxins and 5' nucleotidases can also exert blood pressure lowering activity. Great advances have been made during the last decade regarding the understanding of the mechanism of action of these hypotensive proteins. Bradykinin potentiating peptides exert their action primarily by inhibiting the angiotensin-converting enzyme and increasing the effect of endogenous bradykinin. Snake venom phospholipases A2 are capable of reducing blood pressure through the production of arachidonic acid, a precursor of cyclooxygenase metabolites (prostaglandins or prostacyclin). Other snake venom proteins mimic the effects of ...Continue Reading

References

Mar 1, 1990·The American Journal of Physiology·R T McCarthyP Q Barrett
Aug 5, 1999·Kidney International·O LisyJ C Burnett
Sep 30, 1999·Nature Medicine·D W Cushman, M A Ondetti
Jul 14, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·J HirshV Fuster
Jul 31, 2001·Cardiovascular Research·T SuzukiY Yazaki
Dec 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·Steven D Aird
Jun 25, 2003·Protein Expression and Purification·Liza F FelicoriEladio F Sanchez
Feb 1, 1965·British Journal of Pharmacology and Chemotherapy·S H FERREIRA
Dec 8, 2004·Current Drug Targets. Cardiovascular & Haematological Disorders·Roy JosephR Manjunatha Kini
Apr 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jin YangClaudia S Robertson
May 7, 2005·Toxicon : Official Journal of the International Society on Toxinology·Márcia Regina SoaresMarcelo Ribeiro Vasconcelos Diniz
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Solange M T Serrano, Rachid C Maroun
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Mirian A F Hayashi, Antonio C M Camargo
Nov 18, 2005·Cardiovascular Research·Toshio NishikimiHiroaki Matsuoka
May 5, 2006·Neurochemical Research·Eva Mezey, Michael Brownstein
Jun 28, 2008·Journal of the American College of Cardiology·Ondrej LisyJohn C Burnett
Oct 7, 2008·Toxicon : Official Journal of the International Society on Toxinology·Janaina S A M EvangelistaHelena S A Monteiro
Nov 18, 2008·Journal of Lipid Research·John E Burke, Edward A Dennis
Jan 23, 2009·FEMS Immunology and Medical Microbiology·Atul GoyalSujata Ghosh
Jul 31, 2010·Toxicon : Official Journal of the International Society on Toxinology·R Manjunatha Kini, Robin Doley
Sep 4, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Priscilla D NegraesHenning Ulrich
Dec 7, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Claudiana LameuHenning Ulrich
Dec 15, 2010·Toxicon : Official Journal of the International Society on Toxinology·S VinkP F Alewood
Jan 21, 2011·Current Pharmaceutical Design·Natalie G LumsdenAdrian J Hobbs

❮ Previous
Next ❯

Citations

Dec 5, 2019·Toxins·Félix A UrraRamiro Araya-Maturana
Sep 4, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Carlos A CañasSantiago Castaño-Valencia
Dec 19, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Blaise Adelin TchaouJean-Philippe Chippaux
Dec 12, 2020·Scientific Reports·Agnieszka KlupczynskaJan Matysiak
Dec 29, 2020·Frontiers in Public Health·Keneth Iceland KasoziSusan Christina Welburn
Jun 23, 2020·Toxicon : Official Journal of the International Society on Toxinology·Thiago N MenezesSuely G Figueiredo
May 14, 2021·Forensic Science International : Synergy·Queenie W T ChanLeonard J Foster
May 15, 2021·Biotechnology Advances·Julien GiribaldiChristina I Schroeder
Jun 12, 2021·Toxicon : Official Journal of the International Society on Toxinology·Mayara A RomanelliLucienne S Lara
Sep 18, 2021·Journal of Proteomics·Marco Ruiz-CamposSaulo L Da Silva
Sep 8, 2021·Journal of Proteome Research·Longxiang WangAntoine Dufour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Toxicon : Official Journal of the International Society on Toxinology
Antonio C M CamargoSolange M T Serrano
Blood Cells, Molecules & Diseases
Xiao-Yan DuYun Zhang
© 2021 Meta ULC. All rights reserved