Hypotensive transfusion reactions in the era of prestorage leukoreduction

Transfusion
Monica B PaganoAaron A R Tobian

Abstract

Clinical characteristics of hypotensive transfusion reactions (HyTRs) have not been evaluated in the context of universal prestorage leukoreduction. A retrospective review of medical records of patients with HyTRs during the years 2011 and 2012 was performed at two academic medical institutions. Thirty-five patients with 35 HyTRs were identified, with an incidence of 1.33 per 10,000 transfusions. Red blood cells (RBCs) were implicated in 21 (60.0%) reactions and platelets (PLTs) and plasma (PL) in 11 (31.4%) and three (8.6%), respectively. The HyTR rate per blood component was 0.019% for PLTs, 0.015% for RBCs, and 0.006% for PL. Mean patient age was 65 years (range, 2 months-87 years), five (14.3%) were pediatric (<18 years), and 20 (57.1%) were male. The most frequent clinical settings associated with HyTRs were cardiac surgery (n=13; 37.1%), hematology-oncology diseases (n=11; 31.4%), and general surgery (n=7; 20.0%). Extracorporeal circuits were used within 24 hours before the reaction in 16 patients (45.7%), including nine patients on cardiopulmonary bypass, four on dialysis or continuous venous-venous hemodialysis, and three on extracorporeal membrane oxygenation. Four patients (11.4%) received an angiotensin-converting en...Continue Reading

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Citations

Apr 17, 2016·Lancet·Meghan DelaneyUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Apr 27, 2016·Hematology/oncology Clinics of North America·William J Savage
Jun 11, 2016·Anesthesia and Analgesia·Ryan A MetcalfJennifer Andrews
Dec 15, 2016·Frontiers in Immunology·Olivier GarraudF Cognasse

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