Hypothalamic AMPK and energy balance

European Journal of Clinical Investigation
Miguel López

Abstract

AMP-activated protein kinase (AMPK) is the main cellular energy sensor. Activated following a depletion of cellular energy stores, AMPK will restore the energy homoeostasis by increasing energy production and limiting energy waste. At a central level, the AMPK pathway will integrate peripheral signals (mostly hormones and metabolites) through neuronal networks. Hypothalamic AMPK is directly implicated in feeding behaviour, brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT). It also participates in other metabolic functions: glucose and muscle metabolisms, as well as hepatic function. Numerous anti-obesity and/or antidiabetic agents, such as nicotine, metformin and liraglutide, are known to induce their effects through a modulation of AMPK pathway, either at central or at peripheral levels. Moreover, the weight-gaining side effects of antipsychotic drugs, such as olanzapine, are also mediated by hypothalamic AMPK. Therefore, considering hypothalamic AMPK as a therapeutic target in metabolic diseases appears as an interesting strategy due to its implication in feeding and energy expenditure, the two sides of the energy balance equation.

References

Oct 30, 1985·Biochemical and Biophysical Research Communications·A FerrerF G Hegardt
Jun 1, 1997·European Journal of Biochemistry·D G Hardie, D Carling
Dec 5, 1997·The Journal of Comparative Neurology·P J ShughrueI Merchenthaler
Aug 15, 2000·Medizinische Monatsschrift für Pharmazeuten·U Baum
Jan 18, 2002·Nature·Yasuhiko MinokoshiBarbara B Kahn
Nov 15, 2003·Current Biology : CB·Angela WoodsDavid Carling
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Jan 27, 2004·The Journal of Biological Chemistry·Ulrika AnderssonCaroline J Small
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reuben J ShawLewis C Cantley
Apr 28, 2005·Diabetes·Steven HaffnerUNKNOWN Diabetes Prevention Program Research Group
Jun 28, 2005·The Journal of Biological Chemistry·Rebecca L HurleyLee A Witters
Jan 25, 2006·The Journal of Biological Chemistry·Naoto KubotaTakashi Kadowaki
Jun 8, 2006·Annual Review of Biochemistry·Dario R AlessiJose R Bayascas
Oct 20, 2006·Biochimica Et Biophysica Acta·Zhe ChengJia Li
Dec 7, 2006·The Biochemical Journal·Matthew J SandersDavid Carling
Aug 3, 2007·The Journal of Clinical Investigation·Marc ClaretDominic J Withers
Oct 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Su GaoTimothy H Moran
Nov 6, 2007·Biological & Pharmaceutical Bulletin·So Hui KimChang-Kee Hyun
May 8, 2008·Cell Metabolism·Miguel LópezAntonio Vidal-Puig
Jul 1, 2008·Biochemical and Biophysical Research Communications·Jiyun AhnTaeyoul Ha
Jul 8, 2008·Biochemical and Biophysical Research Communications·Danna M BreenEvangelia Tsiani

❮ Previous
Next ❯

Citations

Aug 20, 2019·Basic & Clinical Pharmacology & Toxicology·Robert KrysiakBogusław Okopień
Feb 20, 2020·Nutrients·Patricia Seoane-CollazoCristina Contreras
Jul 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chian-Jiun LiouWen-Chung Huang
Apr 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mengjiao ZhouLing Li
Nov 30, 2019·Nature Reviews. Endocrinology·Chelsea M LarabeeAna I Domingos
Aug 8, 2019·Journal of Clinical Pharmacology·Robert KrysiakBogusław Okopień
Dec 14, 2019·World Journal of Gastroenterology : WJG·Xue-Yang ChenChao-Hui Yu
Aug 23, 2020·International Journal of Molecular Sciences·Marianna CrispinoMaria Pina Mollica
Oct 20, 2020·Frontiers in Endocrinology·Hailan LiuFang Hu
Jan 6, 2021·Reproductive Biology and Endocrinology : RB&E·Jiayi SunHaibin Kuang
Jan 5, 2021·Frontiers in Endocrinology·Verónica Hurtado-CarneiroCarmen Sanz
May 4, 2020·Neuroscience·Nathalia R V DraganoEdward Milbank
Oct 14, 2020·Neuroscience·Nathalia R V DraganoEdward Milbank
Apr 8, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Khaggeswar BheemanapallyKaren P Briski
Jun 3, 2021·Cells·Jamie I van der VaartRiekelt H Houtkooper
Jun 3, 2021·Pflügers Archiv : European journal of physiology·Breno Picin CasagrandeDebora Estadella
Aug 7, 2021·The FEBS Journal·Ranjithmenon Muraleedharan, Biplab Dasgupta
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans
Oct 28, 2021·Critical Reviews in Food Science and Nutrition·Xiao-Yu XuHua-Bin Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here