PMID: 3751451Jul 1, 1986Paper

Hypothalamic defects in two adult patients with septo-optic dysplasia

Acta Endocrinologica
K S LamR T Yeung

Abstract

Two adult patients with unilateral hypoplastic optic nerves, absent septa pellucida and hypopituitarism are described. Patient 1, aged 20, presented with diabetes insipidus due to partial vasopressin deficiency. Patients 2, aged 29, presented with focal epilepsy. Both had short stature. They showed absent growth hormone (GH) response to insulin-hypoglycaemia or glucagon, but responded to 100 micrograms growth hormone releasing factor (GRF-44) with a rise in circulating GH, suggesting a hypothalamic defect in GH release though a co-existing pituitary defect cannot be excluded. Other hypothalamic-pituitary functions were normal. These two patients probably represent the milder form of the clinical spectrum of septo-optic dysplasia which, with the extensive use of CT brain scans, will be increasingly encountered by physicians attending adult patients.

Citations

Jun 26, 2007·Pituitary·Daniel Kelberman, Mehul Tulsidas Dattani
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M T Dattani
Jun 14, 2000·Clinical Genetics·M T Dattani, I C Robinson
Jan 8, 2000·Acta Paediatrica. Supplement·M T DattaniI C Robinson
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Ameeta MehtaMehul T Dattani

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