PMID: 9548700Apr 21, 1998Paper

Hypothalamic effector neurons and extended circuitries activated in "neurogenic" stress: a comparison of footshock effects exerted acutely, chronically, and in animals with controlled glucocorticoid levels

The Journal of Comparative Neurology
H Y Li, P E Sawchenko

Abstract

Immunolocalization of Fos protein was used to identify and characterize hypothalamic visceromotor populations responsive to acute and chronic intermittent footshock stress, and candidate afferent mediators of hypothalamic effects. Exposure to a single 30 minute footshock session induced maximal Fos expression in the paraventricular hypothalamic nucleus (PVH) 2 hours after the challenge; activated cells corresponded principally to hypophysiotropic neurons expressing corticotropin-releasing factor, with secondary involvement of magnocellular oxytocinergic and autonomic-related projection neurons. Extrahypothalamic cell groups activated in response to acute footshock included ones associated with the processing or modulation of somatosensory/nociceptive inputs, the limbic region of the telencephalon, and visceral sensory mechanisms. Rats with constant corticosterone levels displayed enhanced footshock-induced Fos expression in the parvicellular compartment of the PVH, as well as in certain limbic and somatosensory cell groups, the locus coeruleus, but not in medullary catecholaminergic cell groups. Animals subjected to chronic intermittent stress (2 sessions/day for 7 days) showed only modest evidence of habituation of cellular ac...Continue Reading

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Citations

Dec 1, 2002·Acta Neuropsychiatrica·Alexander W Kusnecov, Alba Rossi-George
Jun 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason J RadleyPaul E Sawchenko
Oct 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Linda Rinaman
Nov 17, 2010·Molecular Psychiatry·B LuscherN Sahir
Mar 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brenda BinghamVictor Viau
Jul 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason J Radley, Paul E Sawchenko
Dec 13, 2007·Neuroimmunomodulation·Jairza Barreto-MedeirosCélia Maria Machado Barbosa de-Castro
Apr 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael TsooryGal Richter-Levin
Feb 19, 2011·Neuroscience and Biobehavioral Reviews·Philip J RyanAndrew L Gundlach
Jul 6, 2010·Behavioural Brain Research·America Augusto ScopinhoSâmia Regiane Lourenço Joca
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cai Song, Hua Wang
May 13, 2008·Behavioural Brain Research·Raquel C R MartinezNewton S Canteras
Jun 10, 2003·Annals of the New York Academy of Sciences·Catherine Rivier
Dec 6, 2003·The European Journal of Neuroscience·I H Miklós, K J Kovács
Dec 17, 2008·Annals of the New York Academy of Sciences·Soon LeeCatherine Rivier
Dec 17, 2008·Annals of the New York Academy of Sciences·Karl EbnerNicolas Singewald
Aug 16, 2008·The European Journal of Neuroscience·Pascal Carrive, Marika Gorissen

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