Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat

Endocrinology
J RoaM Tena-Sempere

Abstract

Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacological characterization of this effect has been mostly conducted in pubertal animals or adult male rodents, whereas similar studies have not been thoroughly conducted in the adult female. In this work, we evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat. Kisspeptin-10 (1 nmol, intracerebroventricular) was able to elicit robust LH bursts at all phases of the estrous cycle, with maximal responses at estrus; yet, in diestrus LH, responses to kisspeptin were detected at doses as low as 0.1 pmol. In contrast, high doses of kisspeptin only stimulated FSH secretion at diestrus. Removal of ovarian sex steroids did not blunt the ability of kisspeptin to further elicit stimulated LH and FSH secretion, but restoration of maximal responses required...Continue Reading

References

Jun 2, 2001·The Journal of Biological Chemistry·A I MuirD C Harrison
Jul 20, 2002·Frontiers in Neuroendocrinology·M Susan Smith, Kevin L Grove
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Yasuko HorikoshiMasahiko Fujino
Aug 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas de RouxEdwin Milgrom
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Mar 31, 2004·Journal of Neuroendocrinology·S ScullionG Leng
Apr 15, 2004·Endocrine Reviews·Robert P MillarStuart R Maudsley
Jun 29, 2004·Biochemical and Biophysical Research Communications·Hisanori MatsuiTetsuya Ohtaki
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sophie MessagerSamuel A J R Aparicio
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Muhammad ShahabTony M Plant
Mar 17, 2005·Endocrinology·Stephanie B Seminara, Ursula B Kaiser
May 28, 2005·Endocrinology·Jeremy T SmithRobert A Steiner
Aug 18, 2005·Endocrinology·Manuel Tena-Sempere
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Waljit S DhilloStephen R Bloom
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seong-Kyu HanAllan E Herbison

❮ Previous
Next ❯

Citations

Mar 14, 2007·Reviews in Endocrine & Metabolic Disorders·Ursula HidenGernot Desoye
Mar 24, 2007·Reviews in Endocrine & Metabolic Disorders·Florent G RevelValérie Simonneaux
Mar 23, 2007·Reviews in Endocrine & Metabolic Disorders·Kei-Ichiro MaedaHiroko Tsukamura
Sep 28, 2010·Brain Research·Paula J Brunton, John A Russell
Nov 9, 2007·Annual Review of Physiology·Simina M PopaRobert A Steiner
Sep 23, 2009·Endocrine Reviews·Amy E OakleyRobert A Steiner
Oct 7, 2011·The Journal of Clinical Endocrinology and Metabolism·Channa N JayasenaWaljit S Dhillo
May 12, 2012·The Journal of Clinical Endocrinology and Metabolism·Yee-Ming ChanStephanie B Seminara
May 23, 2014·PloS One·James S Kinsey-JonesKevin G Murphy
Apr 2, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Rebecca M ReynoldsRobert P Millar
Feb 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Sharon R Ladyman, Barbara Woodside
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Micol S Rothman, Margaret E Wierman
Mar 13, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ali RisvanliNevzat Saat
Mar 1, 2012·Hormones and Behavior·S Retana-MárquezJ A Delgadillo
Aug 7, 2010·General and Comparative Endocrinology·Brian P GroneRussell D Fernald
Mar 30, 2010·Frontiers in Neuroendocrinology·Heather B Patisaul, Wendy Jefferson
Jul 7, 2009·Molecular and Cellular Endocrinology·Horacio J NovairaSally Radovick
Dec 25, 2015·Singapore Medical Journal·Eng Loon Tng
Oct 25, 2008·Peptides·Nicolas RichardMarie-Laure Kottler
Jul 29, 2008·Peptides·C N JayasenaS R Bloom
Sep 18, 2007·Frontiers in Neuroendocrinology·Juan RoaManuel Tena-Sempere
May 19, 2007·Brain Research Reviews·Jeremy T Smith
Feb 28, 2007·General and Comparative Endocrinology·Juan Roa, Manuel Tena-Sempere
May 31, 2008·Journal of Neuroendocrinology·W S Dhillo
Sep 29, 2011·Journal of Neuroendocrinology·D García-GalianoM Tena-Sempere

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.