Hypothalamic expression of Peg3 gene is associated with maternal care differences between SM/J and LG/J mouse strains

Brain and Behavior
S ChiavegattoAndréa C Peripato

Abstract

Maternal care is essential in mammals, and variations in the environment provided by mothers may directly influence the viability of newborns and emotional behavior later in life. A previous study investigated genetic variations associated with maternal care in an intercross of LG/J and SM/J inbred mouse strains and identified two single-locus QTLs (quantitative trait loci). Here, we selected three candidate genes located within these QTLs intervals; Oxt on chromosome 2, and FosB and Peg3 on chromosome 7 and tested their association with maternal care. LG/J females showed impaired postpartum nest building and pup retrieval, a one-day delay in milk ejection, reduced exploratory activity, and higher anxiety-like behavior when compared to SM/J females. The nucleotide sequences of Oxt and FosB were similar between strains, as were their hypothalamic expression levels. Conversely, Peg3 nucleotide sequences showed four nonsynonymous replacement substitutions on LG/J dams, T11062G, G13744A, A13808G, and G13813A, and a 30 base pair (10 aa) in tandem repeat in the coding region with three copies in SM/J and five copies in LG/J. Maternal care impaired LG/J mothers express 37% lower Peg3 mRNA levels in the hypothalamus on the second postp...Continue Reading

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Citations

Oct 12, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carolina P GóesAndréa C Peripato
May 25, 2015·Neuroscience Research·Ana Carolina de MouraMárcia Giovenardi
Jul 16, 2015·BMC Pharmacology & Toxicology·Adriana C VidalCathrine Hoyo

Datasets Mentioned

BETA
HQ679943
HQ679944
HQ679939
and
HQ679940
HQ679941
HQ679942

Methods Mentioned

BETA
PCR
genotyping

Related Concepts

Base Sequence
Chromosomes
Chromosomes, Human, Pair 7
Emotions
Environment
Patient Care
Hypothalamic Structure
Mice, Inbred A
RNA, Messenger
FOSB protein, human

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