Hypothalamic Gene Expression and Postpartum Behavior in a Genetic Rat Model of Depression

Frontiers in Behavioral Neuroscience
Wendy LuoEva E Redei

Abstract

Postpartum depression is a complex illness that often occurs in genetically predisposed individuals. Closely related inbred rat strains are a great resource to identify novel causative genes and mechanisms underlying complex traits such as postpartum behavior. We report differences in these behaviors between the inbred depression model, Wistar Kyoto (WKY) More Immobile (WMI), and the isogenic control Wistar Kyoto Less Immobile (WLI) dams. WMI dams showed significantly lower litter survival rate and frequency of arched back and blanket nursing, but increased pup-directed licking, grooming, and retrieval during postpartum days (PPD) 1-10, compared to control WLIs. This increased pup-directed behavior and the frequency of self-directed behaviors segregated during selective breeding of the progenitor strain of WKY, which is also a depression model. These behaviors are manifested in the WMIs in contrast to those of WLIs. Furthermore, habitual differences in the self-directed behavior between light and dark cycles present in WLIs were missing in WMI dams. Hypothalamic transcript levels of the circadian rhythm-related gene Lysine Demethylase 5A (Kdm5a), period 2 (Per2), and the maternal behavior-related oxytocin receptor (Oxtr), vasop...Continue Reading

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Citations

Aug 11, 2021·Stress : the International Journal on the Biology of Stress·Alice K SchaackEva E Redei

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Methods Mentioned

BETA
Dissection
PCR

Software Mentioned

GraphPad
GraphPad Prism
Applied
Biosystems Primer Express

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