PMID: 3766781Oct 1, 1986Paper

Hypothalamic glutamatergic input to medullary sympathoexcitatory neurons in rats

The American Journal of Physiology
M K Sun, P G Guyenet

Abstract

In the halothane-anesthetized paralyzed rat, electrical or chemical stimulation of lateral hypothalamic sites dorsolateral to the fornix produced pressor effects, increases in lumbar sympathetic nerve discharge (SND), and excitation of the majority of bulbospinal sympathoexcitatory neurons of nucleus paragigantocellularis lateralis (PGCL sympathoexcitatory neurons). The relationship between SND and mean arterial pressure (MAP) was shifted upward by electrical hypothalamic stimulation, whereas the gain of the baroreflex was unchanged. A similar upward shift of the relationship between the discharge rate of PGCL sympathoexcitatory neurons and MAP was observed during stimulation. The excitatory effect of L-glutamate on PGCL sympathoexcitatory neurons was blocked by iontophoretic applications of kynurenic acid, whereas identical amounts of 8-OH kynurenic acid were ineffective. Bilateral pressure injections of kynurenic acid (but not of 8-OH kynurenic acid) into nucleus PGCL markedly reduced the pressor and sympathoexcitatory effects of hypothalamic stimulation without altering the on-going level of SND or its baroreflex inhibition. Applied by iontophoresis, kynurenic acid also attenuated the excitation of PGCL sympathoexcitatory ne...Continue Reading

Citations

Jun 3, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M J KenneyR J Fels
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dmitry N Mayorov, Geoffrey A Head
Nov 1, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry R Dworkin, Susan Dworkin
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S M BarmanH S Orer
May 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuji KayabaTomoyuki Kuwaki
Jun 29, 2012·The Journal of Comparative Neurology·Belinda R BowmanAnn K Goodchild
Nov 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hakan S OrerSusan M Barman
Sep 19, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi KobaTatsuo Watanabe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.