Hypothalamic hamartoma in paediatric patients: clinical characteristics, outcomes and review of the literature

Neurología : publicación oficial de la Sociedad Española de Neurología
C Castaño De La MotaM L Ruiz-Falcó Rojas

Abstract

To describe the epidemiological and clinical-electroencephalographic characteristics, and associated morbidity of patients with hypothalamic hamartoma, as well as the treatment followed and outcomes We have retrospectively reviewed the medical histories of 10 patients diagnosed with hypothalamic hamartoma by magnetic resonance imaging over the last 20 years. The age of onset of epilepsy in patients with hypothalamic hamartoma in our series was between the first days of life and 2 years. Of the 10 total patients, 8 had epileptic seizures during its progress. All of them had gelastic seizures, in addition to other types of seizures, with the most common being partial simple seizures. The electroencephalographic findings recorded were highly variable. One of the patients developed epileptic encephalopathy. Five patients had some kind of conduct disorder. Five patients had cognitive problems. At least 2 different antiepileptic drugs were measured in 8 of the patients who had seizures, and in 6 of these some type of non-pharmacological treatment had been used with the objective of seizure control. Only in 3 of 8 patients has been achieved Acceptable control of epilepsy had only been achieved in 3 out the 8 patients. Five patients of...Continue Reading

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Citations

Jun 4, 2013·Neurosurgical Focus·Sandeep MittalFrederick Andermann
Jan 27, 2015·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·A Jiménez de DomingoA Aguado Del Hoyo
Mar 2, 2017·Case Reports in Medicine·Shervin BadihianJafar Mehvari Habibabadi
Nov 25, 2018·Journal of Clinical Psychology in Medical Settings·Rachel H FeinMarni E Axelrad

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