PMID: 2105631Feb 1, 1990Paper

Hypothalamic hamartomas and sexual precocity. Evaluation of treatment options

American Journal of Diseases of Children
P J StarceskiC J Migeon

Abstract

We describe four male patients with hypothalamic hamartomas associated with sexual precocity. Our assessment of their management suggests that resection using current microsurgical techniques is a valid treatment option if the patient has a normal pubertal endocrine makeup, if the hamartoma is pedunculated, and if the patient is young enough to require years of parenteral medical treatment. Such surgical treatment can be curative, and subsequent growth and development can be normal (patients 1 and 2). However, if the patient is near to pubertal age (patient 3) or if neurosurgical or gonadotropin releasing hormone analogue treatment is not available, the natural history (patient 4) suggests that the only undesirable effects are accelerated growth, tall stature for age, and premature sexual development during childhood, as well as the psychosocial problems that may accompany them. Adult height may be compromised, although the two patients who did not undergo a surgical procedure and did not receive gonadotropin releasing hormone analogue therapy are above the lower limits of the normal range of adult male height. Therefore, if the hamartoma is pedunculated and cessation of pubertal development is desired, resection of the hamarto...Continue Reading

Citations

May 1, 1993·Indian Journal of Pediatrics·M P ColacoR U Mehta
Mar 1, 1997·Indian Journal of Pediatrics·P Colaco
Oct 19, 2002·Progress in Neurobiology·Roberto C MelcangiMariarita Galbiati
Jun 8, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·A A WeissenbergerA J Zametkin
Jan 1, 1993·Neurosurgical Review·S NishioM Fukui
Jul 1, 2010·Neurologia Medico-chirurgica·Shinya YamaguchiToru Iwaki
Jun 1, 1994·Surgical Neurology·N M BoulisP M Black
Mar 5, 2002·Clinical Endocrinology·Carl-Joachim PartschWolfgang G Sippell
Jun 8, 2017·Epilepsia·Victor S HarrisonJohn F Kerrigan
Jan 1, 1994·Clinical Pediatrics·P A Lee
Feb 3, 2005·Pediatric Neurosurgery·S N Shenoy, A Raja
Jan 1, 1993·Journal of Neurosurgery·A L Albright, P A Lee
Jan 1, 1997·Acta neurochirurgica·C G GaposchkinA P Rosiello
Dec 8, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mirjana KocovaElena Sukarova-Angelovska
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·H JungO Dammann
May 26, 2005·Neurologia Medico-chirurgica·Kazunori AritaHiroshi Otsubo
Apr 20, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·S R Ojeda, S Heger
Dec 16, 1998·The American Journal of Surgical Pathology·M C SharmaC Sarkar

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