Hypothalamic-immune interactions. Effect of hypophysectomy on neuroimmunomodulation

Journal of the Neurological Sciences
R J CrossW R Markesbery

Abstract

Electrolyte destruction of certain nuclei of the brain cause specific structural and functional changes in the immune system. Lesions in the preoptic-anterior hypothalamic area result in thymic involution and a decrease in the number and blastogenic reactivity of splenocytes. In contrast, lesions in the hippocampus increase thymic and splenic mitogenic responsiveness and cellularity. Hypophysectomy abrogates all changes in splenocyte number and function induced by hypothalamic and limbic lesions. The effects of ablating the hippocampus and amygdaloid complex on thymocyte number and function also are abolished. Hypothalamic lesions in hypophysectomized animals result in an increase in the number of thymocytes but suppressed mitogenic activity. These data indicated that neuroimmunomodulation is mediated predominantly but not exclusively by the pituitary gland.

Citations

Jan 1, 1987·Journal of Neuroscience Research·R J CrossT L Roszman
Jan 1, 1983·Journal of Neurology·J A Aarli
Feb 1, 1996·The International Journal of Neuroscience·M CheidoL Devoino
Apr 6, 2006·Biological & Pharmaceutical Bulletin·Vanu Ramkumar RamprasathPanchanatham Sachdanandam
Nov 30, 2006·Cell Biology and Toxicology·N Jeya ParthasarathyR Sheela Devi
Feb 1, 1989·Journal of Neuroscience Research·P J NeveuM Le Moal
Feb 1, 1988·The International Journal of Neuroscience·J A RothW E Monroe
Jan 1, 1994·Critical Reviews in Toxicology·B A Fuchs, V M Sanders
Oct 20, 1998·The International Journal of Neuroscience·M PopovićN Popović
Mar 1, 1988·The International Journal of Neuroscience·G Renoux
Nov 1, 1996·Immunopharmacology and Immunotoxicology·I MunnoG F Megna
Aug 25, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·U Fiszer
Aug 1, 1997·Microscopy Research and Technique·U M Moll
Nov 1, 1990·Psychological Medicine·I HickieA Lloyd
Jan 1, 1991·The International Journal of Neuroscience·P BarneoudP J Neveu
Mar 11, 2011·Neuroimmunomodulation·Goutam DuttaTusharkanti Ghosh
Nov 1, 1994·Neuroscience and Behavioral Physiology·M A Cheido, G V Idova
Mar 19, 1999·Brain, Behavior, and Immunity·R Mössner, K P Lesch
Mar 22, 2001·Brain, Behavior, and Immunity·M JurkowskiJ Tokarski
Jun 24, 1998·International Journal of Immunopharmacology·M Cheido, G Idova
Jul 1, 1988·Immunology Letters·P BarneoudP Barneound
Jul 16, 2003·International Immunopharmacology·K MasekJ W Hadden
Apr 1, 1988·Domestic Animal Endocrinology·T H Wise
May 1, 1987·Baillière's Clinical Endocrinology and Metabolism·R C Gaillard, S Al-Damluji

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.