PMID: 7397532Aug 25, 1980Paper

Hypothalamic-immune interactions. I. The acute effect of anterior hypothalamic lesions on the immune response

Brain Research
R J CrossT L Roszman


Rats with electrolytic anterior hypothalamic lesions show changes in lymphoid tissue cellularity and a decrease in the response to concanavalin A (Con A). This effect manifests itself maximally 4 days after lesioning, with a return to normal by day 14. The changes are not mediated through the release of corticosteroids. These data indicate the presence of a neuroendocrine pathway that is capable of modulating immune function.


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