Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: implications for female reproductive aging.

Endocrinology
Brigitte J ToddGenevieve S Neal-Perry

Abstract

Brain IGF-I receptors are required for maintenance of estrous cycles in young adult female rats. Circulating and hypothalamic IGF-I levels decrease with aging, suggesting a role for IGF-I in the onset of reproductive senescence. Therefore, the present study investigated potential mechanisms of action of brain IGF-I receptors in the regulation of LH surges in young adult and middle-aged rats. We continuously infused IGF-I, the selective IGF-I receptor antagonist JB-1, or vehicle into the third ventricle of ovariectomized young adult and middle-aged female rats primed with estradiol and progesterone. Pharmacological blockade of IGF-I receptors attenuated and delayed the LH surge in young adult rats, reminiscent of the LH surge pattern that heralds the onset of reproductive senescence in middle-aged female rats. Infusion of IGF-I alone had no effect on the LH surge but reversed JB-1 attenuation of the surge in young females. In middle-aged rats, infusion of low doses of IGF-I partially restored LH surge amplitude, and infusion of JB-1 completely obliterated the surge. Intraventricular infusion of IGF-I or JB-1 did not modify pituitary sensitivity to exogenous GnRH or GnRH peptide content in the anterior or mediobasal hypothalamus ...Continue Reading

References

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Citations

Oct 11, 2011·Biological Reviews of the Cambridge Philosophical Society·Ben Dantzer, Eli M Swanson
May 21, 2013·Frontiers in Neuroendocrinology·Mei-Fang Cheng
Jun 24, 2010·Maturitas·Genevieve Neal-PerryCary Dicken
Dec 23, 2011·Journal of Neuroendocrinology·G C PanzicaR C Melcangi
Dec 18, 2010·Frontiers in Neuroendocrinology·Anne M EtgenR Suzanne Zukin
Aug 6, 2013·Hormones and Behavior·Jill E SchneiderErin Keen-Rhinehart
Aug 16, 2018·Physiological Reviews·Jennifer W Hill, Carol F Elias
Sep 22, 2018·American Journal of Epidemiology·Alexandra C Purdue-SmitheElizabeth R Bertone-Johnson
Aug 16, 2013·The Journal of Nutrition·Jenny L CarwileKarin B Michels
May 21, 2013·Endocrinology·Andrew Wolfe, Sara Divall
Nov 3, 2020·Frontiers in Cellular Neuroscience·Michal P JurkowskiJoana Gil-Mohapel
Mar 19, 2020·General and Comparative Endocrinology·Cunming Duan, John Allard
Mar 17, 2021·Reproductive Sciences·Jiao LuoYulong Wang

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