Hypothalamic mechanisms mediating glutamate effects on the hypothalamo-pituitary-adrenocortical axis

Journal of Neural Transmission
S Feldman, Joseph Weidenfeld

Abstract

The effect of local administration of glutamate into the hypothalamic paraventricular nucleus (PVN) on the hypothalamo-pituitary adrenocortical (HPA) axis was studied in male rats. Glutamate caused CRH-41 depletion from the median eminence (ME) and a consequent rise in ACTH and corticosterone (CS) serum levels. In rats pretreated with systemic dexamethasone (dex) these effects were completely inhibited. The administration of the glucocorticoid receptor antagonist RU-38486 abolished the inhibitory effect of dex on the adrenocortical discharge. In addition, the depletion of hypothalamic norepinephrine (NE) and serotonin (5-HT) by specific neurotoxins administered into the ventral noradrenergic blundle or into the raphe nuclei respectively, inhibited the response of serum ACTH and CS following PVN glutamate administration. These data indicate that glutamate stimulated the HPA axis via the release of ME CRH-41 into the portal circulation. This response is steroid sensitive involving type II glucocorticoid receptors. Hypothalamic NE and 5-HT participate in the glutamate induced HPA axis activation.

References

Aug 1, 1988·The Journal of Comparative Neurology·E T Cunningham, P E Sawchenko
Dec 15, 1989·Neuroscience Letters·J WeidenfeldS Feldman
Jan 1, 1987·Annals of the New York Academy of Sciences·M T JonesA Di Sciullo
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Jan 1, 1995·Neuroscience and Biobehavioral Reviews·S FeldmanJ Weidenfeld

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Citations

Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·James P HermanWilliam E Cullinan
Sep 11, 2010·Disease Models & Mechanisms·Trupti KawliMan-Wah Tan
Apr 21, 2010·Neurochemical Research·Roberto Farina AlmeidaMarcelo Ganzella
Oct 17, 2015·Interdisciplinary Information Sciences·Nathan K Evanson, James P Herman
Feb 18, 2005·The Journal of Comparative Neurology·Dana R ZieglerJames P Herman
Dec 23, 2004·Journal of Periodontal Research·Torbjørn BreivikFrode Fonnum
Jul 9, 2004·Annals of the New York Academy of Sciences·James P HermanHelmer Figueiredo
Sep 5, 2009·The Journal of Comparative Neurology·Jonathan N FlakJames P Herman
Feb 24, 2015·Physiology & Behavior·Nathan K Evanson, James P Herman
Dec 4, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Cristiane BusnardoFernando M A Correa
Mar 11, 2005·Expert Opinion on Therapeutic Targets·Steven F KendellGerrard Sanacora
Feb 27, 2014·Behavioural Brain Research·Adriana de Toledo RamosLanfranco Ranieri Paolo Troncone
Mar 20, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shang-Feng Gao, Ai-Min Bao
Dec 19, 2017·Frontiers in Neuroscience·Sara AsalgooGila Pirzad Jahromi
Dec 18, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·V A JimenezM Roberto
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T W Bailey, J A Dimicco

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