Hypothalamic miRNAs: emerging roles in energy balance control

Frontiers in Neuroscience
Marc SchneebergerMarc Claret

Abstract

The hypothalamus is a crucial central nervous system area controlling appetite, body weight and metabolism. It consists in multiple neuronal types that sense, integrate and generate appropriate responses to hormonal and nutritional signals partly by fine-tuning the expression of specific batteries of genes. However, the mechanisms regulating these neuronal gene programmes in physiology and pathophysiology are not completely understood. MicroRNAs (miRNAs) are key regulators of gene expression that recently emerged as pivotal modulators of systemic metabolism. In this article we will review current evidence indicating that miRNAs in hypothalamic neurons are also implicated in appetite and whole-body energy balance control.

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Aug 24, 2016·Scientific Reports·Anne DrougardClaude Knauf
Apr 21, 2017·Frontiers in Neuroscience·Adel DerghalLourdes Mounien
Nov 18, 2018·International Journal of Molecular Sciences·Alex Cleber Improta CariaBruno Solano de Freitas Souza
Jul 13, 2019·Frontiers in Endocrinology·Serge H LuquetRiccarda Granata
Apr 21, 2021·Molecular Biology Reports·Sandra Aparecida Benite-RibeiroMônica Rodrigues Ferreira Machado

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