Hypothalamic neuronal histamine regulates body weight through the modulation of diurnal feeding rhythm

Nutrition
H Yoshimatsu

Abstract

Hypothalamic neuronal histamine and its H(1) receptor (H(1)-R), a leptin signaling pathway in the brain, regulate body weight and adiposity by affecting food intake and energy expenditure. Glucagon-like peptide-1 and/or corticotrophin-releasing hormone mediate leptin signaling to neuronal histamine. Leptin-induced suppression of food intake and upregulation of uncoupling protein-1 expression in brown adipose tissue were partially attenuated in histamine H(1)-R knockout (H(1)KO) mice. H(1)KO mice developed maturity-onset obesity. Hyperphagia and decreased energy expenditure assessed by the expression of uncoupling protein-1 mRNA were observed in older (48-wk-old) obese H(1)KO mice but not in younger (12-wk-old) non-obese H(1)KO mice. However, the diurnal feeding rhythm was impaired even in younger non-obese animals. Specifically, disruption of the feeding rhythm developed before the onset of obesity in H(1)KO mice. Correction of these abnormal feeding rhythms with scheduled feeding improved the obesity and associated metabolic disorders in the H(1)KO mice. These findings suggest that histamine H(1)-R is crucial for regulating the feeding rhythm and in mediating the effects of leptin. Early disruption of H(1)-R-mediated functions...Continue Reading

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Citations

Jun 15, 2011·Physiology & Behavior·Karen L Teff, Sangwon F Kim
Jul 14, 2010·Frontiers in Neuroendocrinology·Jere LindénRaimo Pohjanvirta
Jun 24, 2010·Pharmacology, Biochemistry, and Behavior·S S EversA J W Scheurink
May 6, 2015·Neurochemistry International·Martin Maldonado, Kazutaka Maeyama
Jan 22, 2013·Trends in Neurosciences·David A Bechtold, Andrew S I Loudon
Mar 26, 2014·Neuroscience and Biobehavioral Reviews·Erich H SchneiderRoland Seifert
Oct 22, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Ana Maria VolpatoJoão Quevedo
Nov 6, 2014·Journal of Clinical Psychopharmacology·Manabu Takaki, Nobuyuki Okabe
Sep 20, 2017·Journal of Clinical Psychopharmacology·Kensaku Sakae, Hiroyuki Yanagisawa
Sep 8, 2020·Journal of Intellectual Disability Research : JIDR·D VancampfortD Van Biesen
Jun 2, 2011·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hironobu Yoshimatsu

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