PMID: 9437748Jan 23, 1998Paper

Hypothalamic neuropeptide Y and galanin in overweight rats fed a cafeteria diet

Peptides
Patrizia PedrazziM Zoli

Abstract

We evaluated neuropeptide Y (NPY) and galanin (GAL) immunoreactivity (IR) and mRNA in the paraventricular and arcuate nucleus, respectively, in rats that became overweight (Ov) or not (NOv) when fed a cafeteria diet. After 2 months of diet, NOv rats showed a significant increase in NPY IR, whereas Ov rats showed a significant increase in GAL mRNA levels. None of these changes was present in rats overfed for 6.5 months. These differential changes in hypothalamic GAL and NPY transmissions may contribute to the different susceptibility of the two rat subpopulations to the weight-promoting effects of the hypercaloric diet.

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Citations

Apr 24, 2001·Pharmacology & Therapeutics·J C ClaphamM Tadayyon
Oct 19, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J AlexanderS F Leibowitz
May 2, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K L LeibowitzS F Leibowitz
May 12, 2004·Peptides·Sarah F Leibowitz, Katherine E Wortley
Feb 7, 2007·American Journal of Physiology. Endocrinology and Metabolism·G-Q ChangS F Leibowitz
Sep 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Charles PlutJean-Pierre Dausse
Mar 11, 2003·Experimental Biology and Medicine·Magnus M BerglundDonald R Gehlert

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