Hypothalamic nitric oxide synthase gene expression is regulated by thyroid hormones

Endocrinology
Y UetaS L Lightman

Abstract

We investigated the effects of thyroid status on nitric oxide synthase (NOS) gene expression in the rat hypothalamic paraventricular (PVN) and supraoptic nuclei (SON). Propylthiouracil (PTU)-induced hypothyroidism in male rats produced a highly significant reduction in NOS gene transcripts in the PVN and SON, as assessed by quantitative in situ hybridization histochemistry with a specific oligodeoxynucleotide probe. The addition of T3 (40 micrograms/kg) to the PTU-containing diet completely prevented the reduction in NOS transcripts. Hyperthyroidism, induced by adding 160 micrograms/kg T3 to the food, more than doubled the prevalence of NOS transcripts in the PVN and SON after a similar time. Up-regulation of NOS gene transcripts induced by the osmotic stimulus of chronic salt loading was markedly attenuated by PTU-induced hypothyroidism. These results demonstrate a major effect of thyroid status on regulation of NOS gene expression in the hypothalamus.

Citations

Jun 16, 1999·British Journal of Pharmacology·D J GrieveJ Elliott
Jan 5, 2014·Oxidative Medicine and Cellular Longevity·I VillanuevaJ Pacheco-Rosado
Oct 29, 2013·The Journal of Physiological Sciences : JPS·Mitsuhiro YoshimuraYoichi Ueta
Dec 21, 2012·Cellular and Molecular Life Sciences : CMLS·Paola VendittiSergio Di Meo
Sep 21, 2000·Respiration Physiology·E H SchlenkerY N Singh
Jul 9, 2010·Frontiers in Neuroendocrinology·Prasada Rao S Kodavanti, Margarita C Curras-Collazo
Sep 2, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Zahra AkbariGila Behzadi
Mar 24, 2015·The Journal of Reproduction and Development·Lingfa KongGen Watanabe
Jan 25, 2017·Neurology Research International·Yousef BaghcheghiMahmoud Hosseini
Jan 26, 2002·Microscopy Research and Technique·Yoichi UetaStafford L Lightman
Mar 17, 2007·Critical Reviews in Toxicology·R Thomas ZoellerRochelle W Tyl
May 16, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mitsuhiro YoshimuraYoichi Ueta
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·D JaveshghaniS N Hussain
Oct 3, 2001·Physiological Reviews·H E de Wardener
Sep 25, 2001·Experimental Biology and Medicine·K P PatelY Hirooka
Aug 9, 2011·Fertility and Sterility·Paola B NavasGraciela A Jahn
Mar 16, 2005·The Journal of Experimental Biology·Lars O E EbbessonSteffen S Madsen
Apr 17, 1997·Biochemical and Biophysical Research Communications·K ShimizuK Higashi

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