Hypothalamic pathogenesis of type 2 diabetes

Medical Hypotheses
Hiroyuki KoshiyamaHiroki Lkeda

Abstract

There have recently been increasing experimental and clinical evidences suggesting that hypothalamic dysregulation may be one of the underlying mechanisms of abnormal glucose metabolism. First, increased hypothalamic-pituitary-adrenal axis activity induced by uncontrollable excess stress may cause diabetes mellitus as well as dyslipidemia, visceral obesity, and osteoporosis with some resemblance to Cushing's disease. Second, several molecules are known to be expressed both in pancreas and hypothalamus; adenosine triphosphate-sensitive potassium channels, malonyl-CoA, glucokinase, and AMP-activated protein kinase. Those molecules appear to form an integrated hypothalamic system, which may sense hypothalamic fuel status, especially glucose level, and inhibit action of insulin on hepatic gluconeogenesis, thereby forming a brain-liver circuit. Third, hypothalamic resistance to insulin as an adiposity signal may be involved in pathogenesis of peripheral insulin resistance. The results with mice with a neuron-specific disruption of the insulin receptor gene or those lacking insulin receptor substrate 2 in hypothalamus supported this possibility. Finally, it has very recently been suggested that dysregulation of clock genes in hypotha...Continue Reading

References

May 26, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·P BjörntorpR Rosmond
Jul 25, 2000·Diabetes·R M LynchB E Levin
Dec 16, 2000·The New England Journal of Medicine·C Bouchard
Oct 7, 2004·The Journal of Clinical Investigation·Naoto KubotaTetsuo Noda
Jan 22, 2005·Science·Michael W Schwartz, Daniel Porte
Apr 21, 2005·The Journal of Clinical Investigation·Agharul I ChoudhuryDominic J Withers
Apr 23, 2005·Science·Fred W TurekJoseph Bass
Apr 23, 2005·Nature·Fiona M Gribble
Jun 22, 2005·Seminars in Vascular Medicine·Yuji Matsuzawa
Aug 2, 2005·Cell Metabolism·Alessandro PocaiLuciano Rossetti
Aug 6, 2005·Science·Tony K T LamLuciano Rossetti
Aug 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shigeki ShimbaMasakatsu Tezuka
Oct 27, 2005·Diabetes·Alessandro PocaiLuciano Rossetti

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