Hypothalamic-pituitary-adrenal axis response to stress in male DUI recidivists

Accident; Analysis and Prevention
Sophie CoutureRené Carbonneau

Abstract

Cortisol is a stress hormone mediated by the hypothalamic-pituitary-adrenal (HPA) axis and a psychobiological marker of genetic risk for alcoholism and other high-risk behavioural characteristics. In previous work with driving under the influence of alcohol (DUI) recidivists, we uncovered a significant inverse relationship between the frequency of past DUI convictions and salivary cortisol, whose strength surpassed those observed between DUI frequency and measures of alcohol abuse and other DUI-related characteristics. This finding emerged using a methodology not specifically contrived to test this relationship. The goals of this follow-up study were to (a) examine if a standardized stress-induction protocol would produce a significant inverse relationship between cortisol response and number of DUI offences; and (b) clarify whether HPA axis dysregulation could be linked to particular DUI-related behavioural correlates, such as alcohol use severity, sensation seeking, and antisocial features. Thirty male DUI recidivists were recruited as well as 11 male non-DUI drivers as a comparison group. Results indicated an inverse relationship between DUI frequency and cortisol response (r(39)=-0.36, p=0.021), as well as a lower cortisol ...Continue Reading

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Citations

Aug 23, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Sara ShabaniOmid Rezaei
Mar 19, 2016·Physiology & Behavior·Adam BibbeyDouglas Carroll
Jul 24, 2010·Journal of Personality·Hani D Freeman, Jennifer S Beer
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Apr 30, 2015·Substance Abuse : Research and Treatment·Sophie CoutureThomas G Brown

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