Abstract
The hypothalamic-pituitary function of 93 children, who had received central nervous system (CNS) prophylaxis as part of their therapy for acute lymphocytic leukemia (ALL), and who remained in continuous complete remission, was evaluated retrospectively. Treatment regimens included--Group I: 31 subjects, intrathecal methotrexate (IT MTX); Group II: 31 subjects, IT MTX plus 2400 rad cranial irradiation; and Group III: 31 subjects, IT MTX and intravenous intermediate-dose methotrexate. Serum thyroid-stimulating hormone (TSH) and T4 levels were normal. All participants had normal adrenocorticotropic hormone (ACTH) secretion as assessed by plasma cortisol responses to insulin hypoglycemia. Urinary follicle-stimulating hormone (FSH) and luteinizing hormone (LH) excretion of pubertal and postpubertal patients (N = 37) was appropriate, except for one subject from Group I who had an abnormally high output of gonadotropins, and one from Group II who had abnormally low levels. Growth hormone (GH) responses were subnormal after sequential arginine-insulin stimulation as follows--Group 1: 3 of 31 patients; Group II: 6 of 25 patients; and Group III: 2 of 29 patients. Nevertheless, all children had normal linear growth. It was concluded that...Continue Reading
References
Jul 19, 1975·Lancet·S M ShaletD Pearson
Jun 1, 1977·The Journal of Pediatrics·S M ShaletD Pearson
May 1, 1979·The Journal of Pediatrics·S M ShaletD Pearson
May 1, 1978·The Journal of Pediatrics·W P DickinsonM J Elders
Apr 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R PennyS D Frasier
Dec 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R PennyD Frasier
May 1, 1975·The Journal of Clinical Endocrinology and Metabolism·H E KulinA J Ferber
Nov 1, 1969·The Journal of Clinical Endocrinology and Metabolism·R PennyW T Davis
Jan 1, 1983·Acta paediatrica Scandinavica·W BeckG Prindull
Feb 1, 1984·The Journal of Pediatrics·C A RomsheW A Newton
Feb 1, 1984·The Journal of Pediatrics·J BlattD G Poplack
Citations
Jan 1, 1994·International Journal of Clinical & Laboratory Research·L PaganoG Leone
Aug 30, 2000·Medical Oncology·S M Blaney, D G Poplack
Mar 2, 2006·Pituitary·Ken H Darzy, Stephen M Shalet
Jul 1, 1991·Pediatric Neurology·P K Duffner, M E Cohen
Aug 1, 1995·Critical Reviews in Oncology/hematology·S L Berg, D G Poplack
Jul 17, 2001·Clinical Endocrinology·A LandoJ Müller
Nov 3, 2004·The Neurologist·Patricia K Duffner
Aug 1, 1991·Acta Paediatrica Japonica; Overseas Edition·I Tsukimoto
Sep 1, 1995·Acta Paediatrica. Supplement·A Leiper
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenLeslie L Robison
Jul 31, 2009·Cancer Treatment Reviews·Renée L MulderElvira C van Dalen
Apr 16, 2015·The Lancet. Diabetes & Endocrinology·Elizabeth CrowneAndrew Toogood
Jun 29, 2010·Pediatric Blood & Cancer·Alix E SeifSusan R Rheingold
Jan 1, 1987·Medical and Pediatric Oncology·R J PackerG D'Angio
Jul 1, 1997·The Journal of Pediatrics·J RomanL Sierrasesúmaga
Jan 1, 1988·Pediatric Hematology and Oncology·R NygaardF Wesenberg
Jan 1, 1988·Pediatric Hematology and Oncology·M G ZurloA Mancini
Jul 1, 1991·Pediatric Hematology and Oncology·S P DibenedettoM Caruso-Nicoletti
Aug 1, 1989·Cancer·U KeilholzW Hunstein
Sep 1, 1986·Cancer·M L BrecherA I Freeman
Oct 11, 1992·Cancer·J S OlshanT Moshang
Dec 1, 1991·Archives of Disease in Childhood·M UruenaA D Leiper
Apr 1, 1997·Journal of Endocrinological Investigation·A MohnF Angrilli
Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Khyatisha SeejoreRobert D Murray
Dec 26, 2019·BMC Bioinformatics·Jianwei LuTianwei Yu
Aug 3, 2019·The Journal of Clinical Endocrinology and Metabolism·Laura van IerselWassim Chemaitilly