Hypothalamic-pituitary-testicular function in 70 patients with myotonic dystrophy

Journal of Endocrinological Investigation
J A VazquezM A Busturia

Abstract

Hypothalamic-pituitary-testicular function was studied in 70 patients with myotonic dystrophy (MD). The diagnosis was confirmed by electromyography. The mean age of the patients was 36.2 +/- 13.2 yr and the duration of the disease was 11.17 +/- 8.01 yr. Testicular atrophy (testes less than or equal to 12 ml on a Prader orchidometer) was present in 65.5% of patients. Fertility among married patients was 66.6%. Mean testosterone plasma levels were 438 +/- 298 ng/dl vs 520 +/- 185 ng/dl in the control group (P = NS). Basal plasma FSH and LH levels, and their response after the administration of 100 mcg of LH-RH were significantly increased although a wide dispersion was observed. Sperm count was carried out in 27 cases, showing a normal count in 7, oligospermia in 12, and azoospermia in 8 patients. Testicular biopsy was performed in 45 patients being normal in 2, showing mild testicular damage in 8, moderate in 14, and severe in 18; it was nule in 3 of them. A significant relationship between testicular atrophy and the sperm count (p less than 0.01), testicular damage and testicular atrophy (p less than 0.025), and sperm count and testicular damage (p = 0.017) was found. Basal plasma FSH and LH level were significantly related to ...Continue Reading

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Citations

Jan 19, 2008·Journal of Assisted Reproduction and Genetics·Banchhita SahuPaul Serhal
Jun 6, 2008·Journal of Clinical Neuromuscular Disease·Talal M Al-HarbiMark A Tarnopolsky
May 5, 2012·Molecular Endocrinology·Philippe Emmanuel SuarezEdith Hummler
Jan 26, 2016·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
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Jun 16, 2012·International Journal of Endocrinology·Oriana Del Rocío Cruz GuzmánMaricela Rodríguez-Cruz
May 8, 2015·European Journal of Clinical Investigation·Elena PasseriSabrina Corbetta
Jan 26, 2018·Endocrinology, Diabetes & Metabolism Case Reports·Ken TakeshimaTakashi Akamizu
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Jun 15, 2021·The Journal of Clinical Endocrinology and Metabolism·Stephen J Winters

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