PMID: 591468Nov 1, 1977

Hypothalamic thermoregulatory pathways in the rat

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
T M Gilbert, C M Blatteis

Abstract

The cutaneous blood flow (mbl), rate of oxygen consumption (Vo2), rectal (Tre) and cutaneous (Tsk) temperatures, and shivering activity were measured in unanthetized male rats during a 2-h exposure to 26, 33, or 5 degrees C 2 wk after selective bilateral hypothalamic microknife cuts. Animals with preoptic-anterior hypothalamic (PO/AH) junction cuts 1.5 or 3.0 mm lateral to the midline, as well as parasagittal cuts which separated connections between the PO/AH and medial forebrain bundle exhibited a higher mbl at 26 degrees C than did sham-operated rats. At 5 degrees C the extended (3.0 mm) PO/AH cuts as well as the parasagittal cuts prevented cutaneous vasoconstriction but had no effect on shivering activity; hence Tre was not maintained. None of the cuts demonstrably impaired thermoregulation in the 33 degrees C environment. These results suggest that different sites in the hypothalamus may separately control cold-induced skin vasoconstriction and shivering activity, as well as heat-induced skin vasodilation. It would seem therefore that the integrity of the PO/AH is indispensable in rats for cold-induced cutaneous vasoconstriction but not for cold thermogenesis, and also not for heat-induced cutaneous vasodilation.

Citations

Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Clarke G TankersleyRobert Frank
Jan 31, 2002·Anesthesiology·Jan De Witte, Daniel I Sessler
May 4, 2002·Nature Reviews. Neuroscience·J G Sutcliffe, L de Lecea
Apr 26, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrej A RomanovskyWilliam S Hunter
Mar 1, 1985·Clinical Endocrinology·R F Casper, S S Yen
Oct 28, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Takayuki Ishiwata, Benjamin N Greenwood
May 1, 1986·Pflügers Archiv : European journal of physiology·C M Blatteis, M Banet
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zoltan PeterfiJames M Krueger
Dec 2, 2009·European Journal of Applied Physiology·Robin M McAllenMichael J McKinley
Feb 1, 1984·The American Journal of Physiology·M Kiang-Ulrich, S M Horvath

Related Concepts

Heat Loss
Functional Cerebral Localization
Cold Temperature
Denervation
Organum Vasculosum Laminae Terminalis
Supraoptic Hypothalamus
Neural Pathways

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