Hypothalamic Wnt Signalling and its Role in Energy Balance Regulation

Journal of Neuroendocrinology
Gisela Helfer, A Tups

Abstract

Wnt signalling and its downstream effectors are well known for their roles in embryogenesis and tumourigenesis, including the regulation of cell proliferation, survival and differentiation. In the nervous system, Wnt signalling has been described mainly during embryonic development, although accumulating evidence suggests that it also plays a major role in adult brain morphogenesis and function. Studies have predominantly concentrated on memory formation in the hippocampus, although recent data indicate that Wnt signalling is also critical for neuroendocrine control of the developed hypothalamus, a brain centre that is key in energy balance regulation and whose dysfunction is implicated in metabolic disorders such as type 2 diabetes and obesity. Based on scattered findings that report the presence of Wnt molecules in the tanycytes and ependymal cells lining the third ventricle and arcuate nucleus neurones of the hypothalamus, their potential importance in key regions of food intake and body weight regulation has been investigated in recent studies. The present review brings together current knowledge on Wnt signalling in the hypothalamus of adult animals and discusses the evidence suggesting a key role for members of the Wnt si...Continue Reading

References

Dec 1, 1993·Molecular Biology of the Cell·B D SmolichJ Papkoff
Jul 1, 1997·Biology of Reproduction·P D Heideman, C J Sylvester
Aug 11, 2000·Science·S E RossO A MacDougald
Jun 11, 2002·The Journal of Biological Chemistry·Christina N BennettOrmond A MacDougald
Sep 20, 2002·Endocrinology·Tina R IvanovSimon M Luckman
Jun 11, 2004·The Journal of Biological Chemistry·Kenneth A LongoOrmond A MacDougald
Jul 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Preeti H JethwaStephen R Bloom
Jan 18, 2006·Nature Genetics·Struan F A GrantKari Stefansson
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sharoni JacobsRonald M Evans
Jul 21, 2006·The New England Journal of Medicine·Jose C FlorezUNKNOWN Diabetes Prevention Program Research Group
Oct 20, 2006·Development·Ji Eun LeeRichard I Dorsky
Jan 30, 2007·Diabetes·Wendy S WrightOrmond A MacDougald
Feb 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Antje KörnerPeter Kovacs
Sep 14, 2007·The Journal of Comparative Neurology·Maia V KokoevaJeffrey S Flier
Oct 25, 2007·American Journal of Physiology. Endocrinology and Metabolism·Elena A IvanovaAndrew S I Loudon
Mar 21, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mary Anne PotokSally A Camper
Jul 1, 2008·Gene Expression Patterns : GEP·Yu-An HuChunjie Zhao
Oct 1, 2008·The Biochemical Journal·Sasha H Anagnostou, Peter R Shepherd
Apr 21, 2009·Zebrafish·Xu WangRichard I Dorsky
May 4, 2010·Nature Neuroscience·Tomomi ShimogoriSeth Blackshaw
Sep 29, 2011·Nature Reviews. Molecular Cell Biology·Ana G Cristancho, Mitchell A Lazar
Dec 27, 2011·Current Biology : CB·David A BechtoldAndrew S I Loudon
Jan 3, 2012·Endocrinology·Gisela HelferPeter J Morgan
Mar 27, 2012·Nature Neuroscience·Daniel A LeeSeth Blackshaw
Apr 6, 2012·Molecular and Cellular Endocrinology·Sandeep S DhillonDenise D Belsham
May 24, 2012·The EMBO Journal·Roel Nusse, Harold Varmus
Jun 26, 2012·The Journal of Clinical Investigation·Hiroyuki MoriOrmond A Macdougald
Aug 21, 2012·Trends in Endocrinology and Metabolism : TEM·K MarinouM Koutsilieris
Sep 15, 2012·Developmental Cell·Xu WangRichard I Dorsky
Sep 27, 2012·Scientific Reports·Lynda ElghaziErnesto Bernal-Mizrachi
Nov 16, 2012·Nature Reviews. Molecular Cell Biology·Christof Niehrs
Jan 22, 2013·Trends in Neurosciences·Matei Bolborea, Nicholas Dale
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Anna EhrlundMikael Rydén

❮ Previous
Next ❯

Citations

Feb 2, 2018·Journal of Receptor and Signal Transduction Research·Song MaoJianhua Zhang
Apr 21, 2018·Diabetes & Metabolism Journal·Do Kyeong SongMin Seon Kim
Feb 3, 2018·Translational Psychiatry·Susan L McElroyJoanna M Biernacka
Dec 27, 2018·Journal of Neuroendocrinology·Gisela HelferPeter J Morgan
Oct 21, 2016·The Journal of Biological Chemistry·Pedro CisternasNibaldo C Inestrosa
May 13, 2018·Journal of Neuroendocrinology·Hayden J L McEwenDavid R Grattan
Nov 18, 2018·Nutrition Reviews·Rafael BarraAlejandro Hernández
Oct 3, 2018·Autism Research : Official Journal of the International Society for Autism Research·Patrick JachyraAmy C McPherson
Jan 13, 2018·Molecular Genetics and Genomics : MGG·Herman D Cortes, Rachel Wevrick
Sep 22, 2019·Genes·Katarzyna PiórkowskaKatarzyna Ropka-Molik
Jan 5, 2020·Cellular and Molecular Life Sciences : CMLS·Pau GonzálezFrancisco Javier Rodríguez
Jun 18, 2017·Frontiers in Physiology·Alexandre ValléeJean-Noël Vallée
Jul 5, 2019·Expert Review of Neurotherapeutics·Alfredo B Cuellar-BarbozaSusan L McElroy
Oct 19, 2020·Cellular and Molecular Gastroenterology and Hepatology·Chiara LasconiStruan F A Grant
Jan 1, 2021·Archives of Biochemistry and Biophysics·Khaled BenchoulaEng Hwa Wong

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

© 2022 Meta ULC. All rights reserved