Hypothermia and the stress response to cardiopulmonary bypass.

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
D P TaggartD J Wheatley

Abstract

There is no consensus on the optimal level of intraoperative hypothermia during cardiopulmonary bypass (CPB). To assess the effect of systemic cooling on the stress response to CPB, the acute phase and endocrine responses were measured in 20 male patients undergoing elective coronary artery surgery and randomised to an intraoperative blood temperature of 28 degrees C or 20 degrees C. The acute phase response was assessed by changes in the plasma concentration of C-reactive protein (CRP) and the endocrine response by the urinary excretion of the counter-regulatory hormones adrenaline, noradrenaline and cortisol. The groups were comparable with respect to age, anthropometric indices, cross clamp and bypass times. There was no significant difference in the groups in the acute phase response but the endocrine response was attenuated in the 20 degrees C group. These findings may have implications for the severely stressed preoperative patient.

Citations

Mar 14, 2000·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Y HattoriR Hoshino
Mar 1, 1995·British Heart Journal·I M MitchellM P Jamieson
Jan 1, 1993·Scandinavian Journal of Thoracic and Cardiovascular Surgery·A PaccagnellaG Simini
Jan 1, 1991·The American Journal of Physiology·D P TaggartH J Burns
Jan 1, 1991·Annals of Clinical Biochemistry·I M MitchellR W Logan

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