PMID: 9529175Apr 7, 1998Paper

Hypothermia, but not 100% oxygen breathing, prolongs survival time during lethal uncontrolled hemorrhagic shock in rats

The Journal of Trauma
S H KimS Tisherman

Abstract

To test the hypothesis that moderate hypothermia (Hth) (30 degrees C) or breathing 100% oxygen (best with both combined) would prolong survival during lethal uncontrolled hemorrhagic shock (UHS) compared with normothermia (38 degrees C) and breathing air. Forty Sprague-Dawley rats were anesthetized with halothane during spontaneous breathing of N2O/O2 (50:50). UHS was induced by volume-controlled blood withdrawal of 3 mL/100 g over 15 minutes, followed by 75% tail amputation and randomization to one of four UHS treatment groups (10 rats each): group 1 (control) was maintained on room air and rectal temperature of 38 degrees C; group 2 (Hth) was maintained on air and 30 degrees C; group 3 (O2) was maintained on FiO2 100% (starting immediately after tail cut) and 38 degrees C; and group 4 (O2-Hth) was maintained on FiO2 100% and 30 degrees C. Rats were observed otherwise untreated until death (apnea and pulselessness) or for a maximum of 5 hours. During the initial blood withdrawal, mean arterial pressure (MAP) decreased to an average of 24 mm Hg. Seventeen of 40 rats then showed an increase in MAP (attempted self-resuscitation). Induction of hypothermia increased MAP to around 35 mm Hg at 30 minutes but did not increase bleeding...Continue Reading

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Citations

Jan 8, 2000·The Surgical Clinics of North America·S A TishermanP Safar
Dec 1, 2000·Critical Care Medicine·D J Dries
Jul 20, 2002·The Journal of Trauma·Hakan GuvenKayhan Ozkan
Jun 9, 2005·Critical Care Medicine·Henry E WangSamuel A Tisherman
Jun 26, 2009·Critical Care Medicine·Eugene Y Fukudome, Hasan B Alam
Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brett H WaibelMichael F Rotondo
Dec 25, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Tareq KheirbekHasan B Alam
Jan 1, 2013·Global Cardiology Science & Practice·Hesham Saad, Mostafa Aladawy
Feb 5, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Turgut DenizFatih Agalar
Oct 27, 2009·Journal of the American College of Surgeons·Brett H WaibelMichael F Rotondo
May 7, 2010·Journal of Intensive Care Medicine·Robert A Finkelstein, Hasan B Alam
May 29, 1999·AACN Clinical Issues·K S Ahrns, D R Harkins
Jul 14, 2004·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Xin YangLuc Huyghens
Dec 29, 2017·Shock·Andrea WolfGregory J Beilman
Oct 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·James L AtkinsFrederick J Pearce
Oct 4, 2006·Current Opinion in Anaesthesiology·C E Smith, R A Yamat
Nov 21, 2015·Critical Care Medicine·Elisabeth KnöllerSebastian Hafner

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