Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole

American Journal of Physiology. Heart and Circulatory Physiology
Halvard G HiisKurt A Krobert

Abstract

Targeted temperature management is part of the standardized treatment for patients in cardiac arrest. Hypothermia decreases cerebral oxygen consumption and induces bradycardia; thus, increasing the heart rate may be considered to maintain cardiac output. We hypothesized that increasing heart rate during hypothermia would impair diastolic function. Human left ventricular trabeculae obtained from explanted hearts of patients with terminal heart failure were stimulated at 0.5 Hz, and contraction-relaxation cycles were recorded. Maximal developed force (Fmax), maximal rate of development of force [(dF/d t)max], time to peak force (TPF), time to 80% relaxation (TR80), and relaxation time (RT = TR80 - TPF) were measured at 37, 33, 31, and 29°C. At these temperatures, stimulation frequency was increased from 0.5 to 1.0 and to 1.5 Hz. At 1.5 Hz, concentration-response curves for the β-adrenergic receptor (β-AR) agonist isoproterenol were performed. Fmax, TPF, and RT increased when temperature was lowered, whereas (dF/d t)max decreased. At all temperatures, increasing stimulation frequency increased Fmax and (dF/d t)max, whereas TPF and RT decreased. At 31 and 29°C, resting tension increased at 1.5 Hz, which was ameliorated by β-AR stim...Continue Reading

References

May 1, 1992·Circulation·L A MulieriN R Alpert
Jan 1, 1996·Basic Research in Cardiology·G HasenfussH Just
May 1, 2001·Basic Research in Cardiology·J WeisserB Pieske
Jan 5, 2002·Journal of the American College of Cardiology·Michael E LewisRobert S Bonser
Jun 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Charles S ChungSándor J Kovács
Dec 2, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Uwe M FischerSteven J Allen
Dec 15, 2005·Heart, Lung & Circulation·Julieta PalomequeAlicia Mattiazzi
Jun 26, 2009·Critical Care Medicine·Kees H Polderman
Nov 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Ole Magnus FilsethTorkjel Tveita
Jul 2, 2011·Journal of the American College of Cardiology·Donald E SelbyMarkus Meyer
Mar 29, 2012·Advances in Experimental Medicine and Biology·Qing LouIgor R Efimov
Jul 31, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Andreas EspinozaThor Edvardsen
Aug 27, 2013·Annals of Cardiothoracic Surgery·Bulat A Ziganshin, John A Elefteriades
Sep 11, 2014·Neural Regeneration Research·Rami Darwazeh, Yi Yan
Oct 17, 2014·Critical Care Medicine·Kees H Polderman, Joseph Varon
Dec 3, 2014·Seminars in Fetal & Neonatal Medicine·Thomas Wood, Marianne Thoresen
Oct 16, 2015·Intensive Care Medicine·Jerry P NolanUNKNOWN European Society of Intensive Care Medicine

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Citations

Jan 10, 2020·Therapeutic Hypothermia and Temperature Management·Andreas EspinozaPer Steinar Halvorsen
May 29, 2021·European Journal of Pharmacology·Ulrich GergsJoachim Neumann

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