Hypothermia in Multiple Sclerosis: Beyond the Hypothalamus? A Case Report and Review of the Literature

Case Reports in Neurological Medicine
Francesco BertiBruno Gran

Abstract

Hypothermia is a rare and poorly understood complication of Multiple Sclerosis (MS). We report on a 66-year-old patient currently with Secondary Progressive MS (SP-MS) who developed unexplained hypothermia associated with multiple hospitalisations and we review the literature on this topic. In our case, magnetic resonance imaging (MRI) of the brain failed to highlight hypothalamic disease, but spinal MRI identified a number of spinal cord lesions. Given the incidence and clinical significance of spinal involvement in MS and the hypothermic disturbances observed in high Spinal Cord Injury (SCI), we hypothesise that upper spinal cord pathology, along with hypothalamic and brainstem dysfunctions, can contribute to hypothermia.

References

Dec 1, 1992·Acta Neurologica Scandinavica·C GenyJ D Degos
Nov 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·P Byrne, C Clough
Jan 1, 1989·Clinical Neurology and Neurosurgery·M LammensH Carton
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·F SullivanR E Moore
Jan 1, 1969·Brain : a Journal of Neurology·W R ShapiroF Plum
Oct 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·K D WhiteP K Newman
Oct 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·S EdwardsA Whiteley
Jan 6, 2000·Journal of the Neurological Sciences·G Liamis, M Elisaf
Jan 5, 2002·Journal of Neuropathology and Experimental Neurology·I HuitingaD F Swaab
May 9, 2002·American Journal of Physical Medicine & Rehabilitation·Sam C Colachis
Feb 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·R A LinkerH Prange
Mar 28, 2007·The Journal of Spinal Cord Medicine·Sofia KhanKresimir Banovac
Oct 11, 2008·Multiple Sclerosis : Clinical and Laboratory Research·C P GilmoreL Bö
Mar 24, 2009·Journal of Magnetic Resonance Imaging : JMRI·M M VellingaH Vrenken
Jun 16, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Wei QiuAllan G Kermode
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kazuhiro Nakamura
Jun 21, 2015·Neurology·Dean M WingerchukUNKNOWN International Panel for NMO Diagnosis
Aug 8, 2015·Nature Reviews. Immunology·Calliope A DendrouManuel A Friese
Mar 1, 2016·Autonomic Neuroscience : Basic & Clinical·Shaun F Morrison

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.