Hypothermia preserves function and signaling for mitochondrial biogenesis during subsequent ischemia

The American Journal of Physiology
X H NingM A Portman

Abstract

Hypothermia is known to protect myocardium during ischemia, but its role in induction of a protective stress response before ischemia has not been evaluated. As cold incites stress responses in other tissues, including heat shock protein induction and signaling mitochondrial biogenesis, we postulated that hypothermia in perfused hearts would produce similar phenomena while reducing injury during subsequent ischemia. Studies were performed in isolated perfused rabbit hearts (n = 77): a control group (C) and a hypothermic group (H) subjected to decreasing infusate temperature from 37 to 31 degrees C over 20 min. Subsequent ischemia during cardioplegic arrest at 34 degrees C for 120 min was followed by reperfusion. At 15 min of reperfusion, recovery of left ventricular developed pressure (LVDP), maximum first derivative of left ventricular pressure (LV dP/dtmax), LV -dP/dtmax, and the product of heart rate and LVDP was significantly increased in H (P < 0.01) compared with C hearts. Ischemic contracture started later in H (97.5 +/- 3.6 min) than in C (67.3 +/- 3.3 min) hearts. Myocardial ATP preservation and repletion during ischemia and reperfusion were higher in H than in C hearts. mRNA levels of the nuclear-encoded mitochondrial...Continue Reading

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Citations

Apr 20, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elaine LiuAlexandre A Steiner
Jul 31, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Xue-Han NingMichael A Portman
Jan 24, 2007·Journal of Cardiothoracic Surgery·Evaristo CastedoJuan Ugarte
Oct 2, 2014·Therapeutic Hypothermia and Temperature Management·Michael J HerringRobert A Kloner
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin
Mar 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xue-Han NingMichael A Portman
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Samhita S RhodesDavid F Stowe
Sep 26, 2007·European Journal of Anaesthesiology·D YapiciU Oral
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Xue-Han NingMichael A Portman
Apr 27, 2012·In Vitro Cellular & Developmental Biology. Animal·Heng LiZitong Huang
Apr 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·David G BeiserTerry L Vanden Hoek
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Oct 9, 2021·Antioxidants & Redox Signaling·Christopher Spankovich, Bradley J Walters

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