PMID: 8939472Oct 25, 1996Paper

Hypothermia reduces the propensity of cortical tissue to propagate direct current depolarizations in the rat

Neuroscience Letters
S TakaokaD S Warner

Abstract

Both spreading depression (SD) and spontaneous cortical ischemic depolarizations are known to be sensitive to brain temperature. What is unknown is whether this temperature effect is caused by altered sensitivity of cortical tissue to the initiating stimulus or is attributable to an altered ability of cortex to propagate the depolarization wave. To address this, halothane anesthetized rats underwent surface heating/cooling to produce pericranial temperatures of 33 degrees C, 38 degrees C, or 40 degrees C. Spreading depression was first initiated by electrocortical stimulation and then by topical application of KCl. The electrical threshold for SD and the time to direct current shift onset after KCl administration were unaffected by temperature. In contrast, the ability of cortical tissue to propagate the SD wave was temperature dependent. Decreasing temperature from 40 degrees C to 33 degrees C was associated with a slowing of the rate of propagation by 25-30% while the duration of the propagated direct current (DC) shifts was increased by 80% regardless of the initiating stimulus. After elicitation of persistent local DC shift with KCl, the interval between initial waves of SD was progressively increased as temperature was dec...Continue Reading

Citations

Dec 26, 2001·Brain Research. Brain Research Reviews·A Gorji
Apr 8, 1999·Early Human Development·A J Gunn, T R Gunn
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Sonya G WangMirela V Simon
Nov 4, 2009·Neurobiology of Aging·Eszter FarkasFerenc Bari
Oct 31, 2015·Journal of Medical Entomology·Hiroyuki TakaokaAdnan Zaid
Dec 23, 2016·Neurocritical Care·Tadeu A FantaneanuJong Woo Lee
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Aug 25, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leonie SchummJohannes Woitzik

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