PMID: 36572Mar 20, 1979

Hypothermic action of lisuride in rats and differences to bromocriptine in the antagonistic effect of neuroleptics

Naunyn-Schmiedeberg's Archives of Pharmacology
R Horowski


The semisynthetic ergot derivative lisuride induced dose- and time-dependent hypothermia in rats placed in a cold environment (+4 degrees C). As regards dosage, lisuride was more than 100 times more effective in this test model than bromocriptine. The effect of both drugs could be reduced by pretreatment with the dopamine antagonist haloperidol, which indicated a dopaminergic action of both drugs. In contrast, the hypothermic effect of lisuride could not be impaired by pretreatment with sulpiride, whilst the effects of bromocriptine were clearly antagonized by this drug. This results could be explained by a different affinity of these drugs to the same receptors, or, more likely, by a different mechanism of action by which lisuride and bromocriptine activate dopaminergic systems.


Jun 13, 1980·European Journal of Pharmacology·M O CarrubaP Mantegazza
Jul 30, 1982·European Journal of Pharmacology·A M HoloheanJ B Appel
Jul 13, 1984·European Journal of Pharmacology·F Gonzalez-LimaH Ocasio
Apr 1, 1988·Acta Neurologica Scandinavica·P GiovanniniT Caraceni
Dec 1, 1980·Acta Neurologica Scandinavica·M SchachterC D Marsden


Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·A LiuzziR Horowski
Jul 15, 1976·Life Sciences·M TrabucchiL Frattola
Jan 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·W Kehr, W Speckenbach
Apr 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·H Wachtel, N E Andén
Apr 1, 1976·European Journal of Pharmacology·R Horowski, H Wachtel
May 1, 1975·British Journal of Pharmacology·D B CalneJ L Reid
May 1, 1973·The Journal of Pharmacy and Pharmacology·H CorrodiU Ungerstedt

Related Concepts

Antipsychotic Effect
Depression, Chemical
Cold Temperature
Lisuride, (8alpha)-(+-)-Isomer
Hypothermia, Natural

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