PMID: 37302May 1, 1979

Hypothermic effects of apomorphine homologues in mice

The Journal of Pharmacy and Pharmacology
M K MenonJ G Cannon

Abstract

A single intraperitoneal (i.p.) injection in mice of apomorphine (I) and its analogues norapomorphine (II), N-ethylnorapomorphine (III), N-n-propylnorapomorphine (IV) and apocodeine (V), caused dose-related decreases in deep-core body temperature. The neuroleptic agent haloperidol blocked the hypothermia produced by these apomorphines but alpha-methyl-p-tyrosine failed to do so. This indicated a direct post-synaptic stimulation of dopamine receptors. Methysergide potentiated the hypothermic effect of the apomorphine analogues. Taking the amount of apomorphine to produce a 3 degree C fall in temperature at 30 min as unity, the approximate relative potencies were: I 1.00, II 0.06, III 47.50, IV 85.00, V 0.340. The doses of the apomorphines needed to produce hypothermia were much less than those needed to cause stereotypy. The ratios of the minimal doses required to produce hypothermia, to those producing stereotypy were: I 8.82, II 4.00, III 125.00, IV 28.50, V 1.43.

References

Jan 1, 1992·Psychopharmacology·M R Zarrindast, F Abolfathi-Araghi
May 8, 1981·European Journal of Pharmacology·D J DooleyD M Bowden
Jan 1, 1995·Journal of Psychopharmacology·M R ZarrindastA Amiri

Citations

Oct 1, 1976·The Journal of Pharmacy and Pharmacology·M K MenonJ G Cannon
Jan 1, 1976·International Review of Neurobiology·F C ColpaertJ E Leysen
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M TitelerP Seeman
Oct 1, 1975·Journal of Medicinal Chemistry·E R AtkinsonF C Nachod
Sep 1, 1977·British Journal of Pharmacology·B Cox, T F Lee
Jul 1, 1973·European Journal of Pharmacology·M GrabowskaL Antkiewicz
Sep 1, 1972·The Journal of Pharmacy and Pharmacology·K Fuxe, F Sjöqvist
Oct 1, 1974·Journal of Medicinal Chemistry·W S Saari, S W King
Sep 1, 1968·Journal of Medicinal Chemistry·M V KochA M Burkman

Related Concepts

Hypothermia, Natural
Haldol
Stereotyped Behavior
Methyltyrosines
Sansert
Apokinon

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