Hypothesis: cyclical histogenesis is the basis of circannual timing

Journal of Biological Rhythms
David G Hazlerigg, Gerald A Lincoln

Abstract

Circannual rhythms are innately timed long-term (tau ≈ 12 months) cycles of physiology and behavior, crucial for life in habitats ranging from the equator to the Poles. Here the authors propose that circannual rhythm generation depends on tissue-autonomous, reiterated cycles of cell division, functional differentiation, and cell death. They see the feedback control influencing localized stem cell niches as crucial to this cyclical histogenesis hypothesis. Analogous to multi-oscillator circadian organization, circannual rhythm generation occurs in multiple tissues with hypothalamic and pituitary sites serving as central pacemakers. Signals including day length, nutrition, and social factors can synchronize circannual rhythms through hormonal influences, notably via the thyroid and glucocorticoid axes, which have profound effects on histogenesis. The authors offer 4 arguments in support of this hypothesis: (1) Cyclical histogenesis is a prevalent process in seasonal remodeling of physiology. It operates over long time domains and exhibits tissue autonomy in its regulation. (2) Experiments in which selected peripheral endocrine signals are held constant indicate that circannual rhythms are not primarily the product of interacting ...Continue Reading

References

Sep 1, 1978·The Journal of Endocrinology·J HerbertD H Thorpe
Feb 1, 1976·The Journal of Experimental Zoology·Gerald A Lincoln, T J Fletcher
Jul 1, 1988·Journal of Reproduction and Fertility·Andrew Loudon, J D Curlewis
Apr 1, 1981·General and Comparative Endocrinology·N E HendersonR P Meronek
Aug 27, 1981·Nature·J H Poole, C J Moss
Sep 1, 1996·Journal of Reproduction and Fertility·Gerald A Lincoln, W D Ratnasooriya
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·G E BentleyG F Ball
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·P D LambertS J Wiegand
Jul 21, 2001·Seminars in Cell & Developmental Biology·E D Herzog, G Tosini
Jun 20, 2002·Endocrinology·Heather J BillingsGreg M Anderson
Jul 13, 2002·The Journal of Pathology·Stuart ForbesMalcolm Alison
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Donald Y M Leung, John W Bloom
Feb 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jonathan D JohnstonDavid G Hazlerigg
Aug 18, 2004·Annals of the New York Academy of Sciences·Fernando Nottebohm
Feb 22, 2005·Current Opinion in Neurobiology·Fiona Doetsch, Rene Hen
Feb 25, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G F LemkineB A Demeneix
Mar 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Alex M SchreiberDonald D Brown
Mar 10, 2005·Experimental Neurology·Yi XuChizuka Ide
May 12, 2005·PLoS Biology·Fernando Nottebohm
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Jul 26, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Yosuke MiyazakiHideharu Numata
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Donald D Brown
Dec 14, 2005·International Review of Cytology·Esteban M RodríguezPedro Amat
Jan 13, 2006·The New England Journal of Medicine·Ching-Hon Pui, William E Evans
Apr 18, 2006·Cell·Noriaki KondoTakashi Ohtsu
May 12, 2006·Chronobiology International·Gerald A Lincoln
Dec 23, 2006·Science·Gerald A LincolnDavid G Hazlerigg
Aug 9, 2007·PLoS Biology·David DupretDjoher Nora Abrous
Sep 21, 2007·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Yosuke MiyazakiHideharu Numata
Dec 18, 2007·Journal of Neuroendocrinology·Andy Levy
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Teddy FauquierIain C A F Robinson
Mar 21, 2008·Nature·Nobuhiro NakaoTakashi Yoshimura
Apr 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anatoli S GleibermanGrigori Enikolopov
May 20, 2008·Journal of Biological Rhythms·Duncan J Macgregor, Gerald A Lincoln
Aug 5, 2008·Current Biology : CB·Elodie A HanonDavid G Hazlerigg
Sep 13, 2008·Current Biology : CB·David G Hazlerigg, Andrew Loudon
Nov 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hiroko OnoTakashi Yoshimura
Jan 10, 2009·Journal of Insect Physiology·Yosuke MiyazakiHideharu Numata
Feb 13, 2009·Current Biology : CB·Marlon R SchneiderRalf Paus
Mar 14, 2009·PloS One·Montse Garcia-LavandeiraClara V Alvarez
Mar 24, 2009·Journal of Neuroendocrinology·L A Nolan, A Levy
Sep 17, 2009·Journal of Biological Rhythms·Stefanie MoneckePaul Pévet
May 4, 2010·Current Biology : CB·Sandrine M DupréAndrew Loudon
May 7, 2010·Proceedings. Biological Sciences·Matthew P ButlerMichael R Gorman
Oct 5, 2010·Cell Stem Cell·Amanda SierraMirjana Maletic-Savatic
Dec 7, 2010·Current Biology : CB·H DardenteDavid G Hazlerigg
Dec 15, 2010·The European Journal of Neuroscience·Hugo Vankelecom
Jan 1, 2010·Society of Reproduction and Fertility Supplement·Gerald A Lincoln, David G Hazlerigg

Citations

Feb 6, 2013·Environmental Health and Preventive Medicine·Samuli HelamaTimo Partonen
May 28, 2013·Molecular and Cellular Endocrinology·Thomas DickmeisMeltem Weger
Jul 12, 2012·Biological Reviews of the Cambridge Philosophical Society·Philipp ZerbeDennis W H Müller
Mar 25, 2014·Journal of Translational Medicine·Adriano Barreto NogueiraManoel Jacobsen Teixeira
Jan 4, 2013·Journal of Neuroendocrinology·Cristina Sáenz de MieraDavid G Hazlerigg
Oct 16, 2015·Proceedings. Biological Sciences·T J StevensonBarbara Helm
Dec 3, 2014·Frontiers in Neuroendocrinology·Francis Ebling
Jul 2, 2014·Current Biology : CB·Cristina Sáenz de MieraValérie Simonneaux
Oct 1, 2013·Cell Reports·Juliane ZantkeKristin Tessmar-Raible
May 15, 2016·Theriogenology·Martine MigaudMartine Batailler
Aug 10, 2013·Journal of Biological Rhythms·Stefanie MoneckePaul Pévet
Oct 11, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Susanne ÅkessonBarbara Helm
Apr 23, 2016·The Journal of Experimental Biology·Arnoldus Schytte Blix
Dec 27, 2018·Journal of Neuroendocrinology·Gisela HelferPeter J Morgan
Feb 11, 2019·Journal of Neuroendocrinology·Gerald A Lincoln
Jul 5, 2013·Proceedings. Biological Sciences·Barbara HelmDavide Dominoni
Apr 6, 2018·Journal of Biological Rhythms·Cristina Sáenz de MieraStefanie Monecke
May 7, 2019·Journal of Neuroendocrinology·H DardenteCristina Sáenz de Miera
Oct 5, 2017·Cellular and Molecular Life Sciences : CMLS·Didier LometH Dardente
Sep 9, 2020·Annual Review of Cell and Developmental Biology·Sarah M MohrElena O Gracheva
Feb 4, 2021·Proceedings of the National Academy of Sciences of the United States of America·Avichai TendlerUri Alon

Methods Mentioned

BETA
transgenic

Related Concepts

Ultradian Cycles
Oscillators, Biological
Cues
Feedback - System Communication
Hormones
Seasonal Variation
Light Cycle
Cell Death
Cell Differentiation Process
Cell Division

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.