PMID: 8583957May 1, 1995Paper

Hypothesis explaining simultaneous development of acquired immunodeficiency syndrome and malignant tumors

Medical Hypotheses
G K Gogichadze, T G Dolidze

Abstract

A possible mechanism for explanation of the simultaneous development of acquired immunodeficiency syndrome (AIDS) and malignant tumors may be based on the cell-fusion process with the participation of immunocompetent cells. If the fusion proceeds with a high intensity, i.e. a great number of cells (including immunocompetent cells) are involved in the process, it will cause a rise in multinuclear formations-polykaryocytes. Since polykaryocytes are incapable of proliferation, their formation is equivalent to elimination of immunocompetent cells and may lead to immunodeficiency. If the intensity of fusion is low, the occurrence of binuclear formations- dikaryons-seems more frequent. We have shown (1) a possibility of the transformation of dikaryons into tumor cells under certain conditions and since immunocompetent cells are dominant by their phenotypic properties the malignant cells in AIDS should have mainly macrophage, lymphoid or intermediate morphology. Even low doses of various chemical carcinogens may cause malignancy by the formation of special defects in plasma membrane which promote cell fusion, whereas under high doses of carcinogens (or high intensity of their action) the formation of polykaryocytes and the development...Continue Reading

References

Jun 1, 1990·Journal of the American Academy of Dermatology·G StinglM Popovic

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Citations

Jun 15, 2005·Medical Hypotheses·G K Gogichadze, T G Gogichadze
Sep 27, 2005·Medical Hypotheses·G K GogichadzeT G Gogichadze
Sep 23, 2000·Medical Hypotheses·G K Gogichadze, A V Gedenidze

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