Abstract
The reactive airways dysfunction syndrome (RADS), the reactive upper airways dysfunction syndrome (RUDS), the sick building syndrome (SBS), and the multiple chemical sensitivity syndrome (MCS) are overlapping disorders in which there is an intolerance to environmental chemicals. The onset of these illnesses is often associated with an initial acute chemical exposure. To understand the pathophysiology of these conditions, a study of the nasal pathology of individuals experiencing these syndromes was undertaken. Preliminary data indicate that the nasal pathology of these disorders is characterized by defects in tight junctions between cells, desquamation of the respiratory epithelium, glandular hyperplasia, lymphocytic infiltrates, and peripheral nerve fiber proliferation. These findings suggest a model for a relationship between the chronic inflammation seen in these conditions and an individual's sensitivity to chemicals. A positive feedback loop is set up: the inflammatory response to low levels of chemical irritants is enhanced due to the observed changes in the epithelium, and the epithelial changes are propagated by the inflammatory response to the chemicals. This model, combined with the concept of neurogenic switching, ha...Continue Reading
References
May 1, 1992·Archives of Environmental Health·S R WillesR Bascom
Jun 1, 1991·The American Review of Respiratory Disease·R BascomD Proud
Dec 1, 1988·Archives of Otolaryngology--head & Neck Surgery·R L DotyA Shapiro
Jan 1, 1989·The Journal of Allergy and Clinical Immunology·C A Leslie, A A Mathé
Jan 1, 1986·The American Journal of Medicine·C Shim, M H Williams
Sep 1, 1985·Chest·S M BrooksI L Bernstein
Dec 1, 1982·Brain Research·Y GozesI Gozes
Jan 1, 1995·Environmental Health Perspectives·W J Meggs
Aug 1, 1993·Environmental Health Perspectives·W J Meggs
Feb 1, 1993·Chest·B DanuserH Krueger
Jan 1, 1993·Archives of Environmental Health·W J Meggs, C H Cleveland
Dec 1, 2001·Journal of Substance Abuse Treatment·L M LundgrenK Davis
Citations
Mar 1, 1997·Environmental Health Perspectives·H Kipen, N Fiedler
Feb 19, 2000·The Laryngoscope·J H ChoH R Yoon
Oct 26, 2005·Archives of Environmental Health·Martin L Pall, Julius H Anderson
Apr 29, 2010·Current Allergy and Asthma Reports·J Wesley Sublett, David I Bernstein
Feb 12, 2000·The Journal of Allergy and Clinical Immunology·N PoonaiS M Tarlo
Oct 8, 2011·Immunology and Allergy Clinics of North America·J Wesley Sublett, David I Bernstein
Oct 6, 2010·The Science of the Total Environment·Stephen J Genuis
Apr 17, 2016·Immunology and Allergy Clinics of North America·Leslie C Grammer
Dec 19, 2007·Parasite Immunology·A Jarillo-LunaS Rojas-Hernández
Apr 15, 2004·Brain Research·Barbara A SorgMatthew L Tschirgi
Jun 6, 2002·International Journal of Hygiene and Environmental Health·Bernadette Eberlein-KönigJohannes Ring
Jan 7, 2003·Clinics in Chest Medicine·Ron Balkissoon
Nov 29, 2014·Current Allergy and Asthma Reports·Whitney W Stevens, Leslie C Grammer
Nov 9, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A SiracusaA Marabini
May 14, 2005·Journal of Occupational and Environmental Medicine·Stanley M Caress, Anne C Steinemann
Jul 23, 1999·Toxicology and Industrial Health·W J Meggs
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin L Pall
Jun 26, 2020·Antibodies·Tamara Tuuminen
Apr 20, 2018·Drug Safety - Case Reports·Allan Lieberman, Luke Curtis
Jan 4, 2006·Proceedings·R V Lee
Mar 20, 1998·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·I R BellJ M Peterson
Sep 1, 2003·Environmental Toxicology and Pharmacology·Christoph van ThrielClaus Bachert