Abstract
The STAT transcription factors are mediators of signal transduction of a variety of factors, including interferons (IFNs), interleukins, growth factors, and peptide hormones. Subsequent to activation, STATs are translocated to the nucleus apparently through the well-described importin/Ran system, where they activate target genes. Molecules utilizing this nuclear import system require specific nuclear localization sequences (NLSs). Paradoxically, such NLSs are not identifiable on STATs, thus raising the question of how they are imported into the nucleus. Of considerable interest is the observation that ligands and/or receptors that signal through STATs contain putative NLSs and, where examined, either ligand or receptor undergoes nuclear translocation. We hypothesize that ligands and/or their receptors serve as vehicles for the nuclear translocation of STATs, and that they may be directly involved in signal transduction. Using IFNgamma as a model system, we provide a possible mechanism for how this direct role is fulfilled. A functional NLS has been identified in a C-terminal domain of IFNgamma. This domain and the NLS contained within are crucial for the biological properties of IFNgamma in that a peptide encompassing this doma...Continue Reading
Citations
Dec 10, 1999·Molecular Biology of the Cell·S G Pasion, S L Forsburg
Nov 30, 2000·Arthritis Research·R A OrtmannJ J O'Shea
Nov 30, 2011·PloS One·Fujun HanBiliang Zhang
Jul 7, 2009·Molecular Immunology·Leon Grayfer, Miodrag Belosevic
May 11, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Fujun HanWei Li
Aug 14, 2003·Science's STKE : Signal Transduction Knowledge Environment·Kevin M McBride, Nancy C Reich
Jun 13, 2000·Oncogene·J HerringtonC Carter-Su
Jul 7, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J LarkinH M Johnson
Oct 16, 1999·Hypertension·R Re
Sep 8, 2000·Molecular Endocrinology·H Favre-YoungA de Luze
May 16, 2000·Molecular Endocrinology·E S ParkM Shong
Jun 28, 2001·Oncogene·J Turkson, R Jove
Jul 31, 1999·The Journal of Biological Chemistry·A V KazanskyJ M Rosen
May 1, 2002·The Journal of Biological Chemistry·Jonathan G DrachmanKenneth Kaushansky
Feb 7, 2007·The Journal of Biological Chemistry·Sheng-Chieh Hsu, Mien-Chie Hung