PMID: 6537244Jan 1, 1984Paper

Hypothesis testing in patients with chronic progressive multiple sclerosis

Brain and Cognition
S M Rao, T A Hammeke

Abstract

Patients with chronic progressive MS (N = 38) were compared with an age and education matched medical control group (N = 19) on a visual discrimination task designed to evaluate hypothesis testing and focusing behavior. Thirty-three MS patients (85%) and all control patients were able to formulate and use hypotheses, but MS patients were less likely to employ strategies leading to a correct solution. Furthermore, MS patients were more likely to perseverate with one strategy despite negative verbal feedback. Five MS patients were unable to formulate hypotheses. These findings suggest that MS patients have impaired cognitive functioning in addition to previously reported problems with memory.

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Citations

Apr 1, 1989·Journal of the Neurological Sciences·A Jennekens-SchinkelJ B Lanser
Apr 15, 1999·Journal of the Neurological Sciences·S LaatuJ Ruutiainen
Oct 1, 1986·Journal of Clinical and Experimental Neuropsychology·S M Rao
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Mar 1, 1996·Journal of the International Neuropsychological Society : JINS·W W Beatty, N Monson

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