Hypothesis tests for stratified mark-specific proportional hazards models with missing covariates, with application to HIV vaccine efficacy trials

Biometrical Journal. Biometrische Zeitschrift
Yanqing SunPeter B Gilbert

Abstract

This article develops hypothesis testing procedures for the stratified mark-specific proportional hazards model with missing covariates where the baseline functions may vary with strata. The mark-specific proportional hazards model has been studied to evaluate mark-specific relative risks where the mark is the genetic distance of an infecting HIV sequence to an HIV sequence represented inside the vaccine. This research is motivated by analyzing the RV144 phase 3 HIV vaccine efficacy trial, to understand associations of immune response biomarkers on the mark-specific hazard of HIV infection, where the biomarkers are sampled via a two-phase sampling nested case-control design. We test whether the mark-specific relative risks are unity and how they change with the mark. The developed procedures enable assessment of whether risk of HIV infection with HIV variants close or far from the vaccine sequence are modified by immune responses induced by the HIV vaccine; this question is interesting because vaccine protection occurs through immune responses directed at specific HIV sequences. The test statistics are constructed based on augmented inverse probability weighted complete-case estimators. The asymptotic properties and finite-samp...Continue Reading

References

Mar 21, 2003·Nature·Xiping WeiGeorge M Shaw
May 8, 2004·Lifetime Data Analysis·Peter B GilbertYanqing Sun
Jun 7, 2007·PloS One·David C NickleSergei L Kosakovsky Pond
Jul 26, 2008·Science·Anthony S FauciWarner C Greene
Sep 19, 2009·PLoS Pathogens·Penny L MooreUNKNOWN NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Oct 20, 2009·Annals of Statistics·Yanqing SunIan W McKeague
Oct 22, 2009·The New England Journal of Medicine·Supachai Rerks-NgarmUNKNOWN MOPH-TAVEG Investigators
Mar 2, 2011·Nature Medicine·Morgane RollandJames I Mullins
Mar 23, 2013·Scandinavian Journal of Statistics, Theory and Applications·Yanqing Sun, Peter B Gilbert
Mar 21, 2016·Lifetime Data Analysis·Yanqing SunPeter B Gilbert

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Citations

Nov 17, 2020·Journal of the Royal Statistical Society. Series C, Applied Statistics·Yanqing SunPeter B Gilbert

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