PMID: 9165404Mar 1, 1997Paper

Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: proposed role of synaptic reorganization

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
F E Dudek, M Spitz

Abstract

This review article evaluates the hypothetical cellular mechanisms responsible for chronic lesion-induced epilepsy. Emphasis is given to particular clinical characteristics of secondary epileptogenesis: (a) a temporal latency, (b) the involvement of distant but related sites, and (c) irreversibility. Although loss of GABAergic inhibitory interneurons or increased excitatory input to these interneurons may contribute to epileptogenesis, several studies have provided evidence that inhibition is not depressed in epileptogenic regions and may actually be enhanced. Axonal sprouting, synaptic reorganization, and formation of new recurrent excitatory circuits have been proposed to account for the increased seizure susceptibility of temporal lobe epilepsy. Recent data support the hypothesis that local inhibitory circuits mask the multisynaptic excitatory interactions that are associated with mossy fiber sprouting in the dentate gyrus and that physiological mechanisms that reduce inhibition or increase excitability unmask the new recurrent excitatory circuits responsible for seizures. A hypothesis based on axonal sprouting and synaptic reorganization can account for the essential clinical characteristics of secondary epileptogenesis and...Continue Reading

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Citations

Oct 30, 2009·Journal of Computational Neuroscience·Zachary P Kilpatrick, Paul C Bressloff
May 4, 2004·Epilepsy Research·Ronald S WinokurBret N Smith
Jan 13, 2001·Brain Research. Developmental Brain Research·S W SuD Silveira
Jun 28, 2000·Neuroscience·N Franco-PonsG Danscher
Mar 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J E Cibula, R L Gilmore
May 28, 2008·Epilepsia·Aimee F Luat, Harry T Chugani
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert F HuntBret N Smith
Jul 25, 2006·Neurosurgical Focus·Sergio PaoliniVincenzo Esposito
Jan 2, 2014·International Journal of Molecular Sciences·Hanna Algattas, Jason H Huang
May 11, 2011·Pharmacology & Therapeutics·Ashok K Shetty
Sep 21, 2010·Epilepsy & Behavior : E&B·Eva Assem-HilgerSusanne Asenbaum
Nov 18, 2008·Experimental Neurology·Robert F HuntBret N Smith
Apr 15, 2008·Neurochemistry International·Zhi-Hong ChiZhan-You Wang
Oct 6, 2004·Epilepsia·Philip A WilliamsF Edward Dudek
May 29, 2003·IEEE Transactions on Bio-medical Engineering·Leon D Iasemidis
Sep 6, 2005·Epilepsy & Behavior : E&B·Cristiane Queixa TilelliNorberto Garcia-Cairasco
Aug 24, 2005·Seminars in Pediatric Neurology·John F KerriganHarold L Rekate
Sep 21, 2013·Cerebral Cortex·C M FlorezT A Valiante
Nov 11, 2016·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Vladimir ShvartsDavid Burdette
Mar 7, 2014·The Cochrane Database of Systematic Reviews·David Gloss, Barbara Vickrey
Aug 5, 2005·Biological & Pharmaceutical Bulletin·In-Sun ChoiByung-Ju Choi
Jun 25, 2019·Epilepsy Currents·Helen E Scharfman

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