Hypothetical Proteins as Predecessors of Long Non-coding RNAs.

Current Genomics
Girik MalikPrashanth Suravajhala

Abstract

Hypothetical Proteins [HP] are the transcripts predicted to be expressed in an organism, but no evidence of it exists in gene banks. On the other hand, long non-coding RNAs [lncRNAs] are the transcripts that might be present in the 5' UTR or intergenic regions of the genes whose lengths are above 200 bases. With the known unknown [KU] regions in the genomes rapidly existing in gene banks, there is a need to understand the role of open reading frames in the context of annotation. In this commentary, we emphasize that HPs could indeed be the predecessors of lncRNAs.

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Citations

Sep 8, 2021·Physiological Genomics·Nidhi ShuklaPrashanth Suravajhala

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Software Mentioned

MapReduce
BLAST
Osprey
LncRNAs
Noncode Blast
CHAT
Lncipedia
house
UniParc

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