Hypothyroidism after Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study

Radiation Research
Peter D InskipJay H Lubin

Abstract

While thyroid cancer risks from exposure to ionizing radiation early in life are well characterized quantitatively, the association of radiation with nonmalignant, functional thyroid disorders has been less studied. Here, we report on a risk analysis study of hypothyroidism with radiation dose to the thyroid gland and the hypothalamic-pituitary axis among survivors of childhood cancer. Utilizing data from the Childhood Cancer Survivor Study, a cohort of 14,364 five-year survivors of childhood cancer diagnosed at 26 hospitals in the U.S. and Canada between 1970 and 1986 and followed through 2009, the occurrence of hypothyroidism was ascertained among 12,015 survivors through serial questionnaires. Radiation doses to the thyroid gland and pituitary gland were estimated from radiotherapy records. Binary outcome regression was used to estimate prevalence odds ratios for hypothyroidism at five years from diagnosis of childhood cancer and Poisson regression to model incidence rate ratios (RR) after the first five years. A total of 1,193 cases of hypothyroidism were observed, 777 (65%) of which occurred five or more years after cancer diagnosis. The cumulative proportion affected with hypothyroidism (prevalence at five years after can...Continue Reading

References

Aug 29, 1991·The New England Journal of Medicine·S L HancockI R McDougall
Mar 1, 1990·Baillière's Clinical Endocrinology and Metabolism·M D LittleyC G Beardwell
Sep 1, 1989·Clinical Endocrinology·M D LittleyM L Sutton
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·S L HancockL S Constine
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·C SklarL Robison
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·Hanneke M van SantenCor van den Bos
Feb 13, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Susan R RoseMelissa M Hudson
Oct 27, 2004·Journal of Clinical Epidemiology·Ann C MertensLeslie L Robison
Jul 5, 2006·Journal of the National Cancer Institute·Charles A SklarLeslie L Robison
Apr 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Niranjan BhandareWilliam M Mendenhall
Feb 14, 2008·Pituitary·Ken H Darzy, Stephen M Shalet
Oct 23, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Masanobu Yamada, Masatomo Mori
Dec 9, 2008·American Journal of Clinical Oncology·Niranjan BhandareWilliam M Mendenhall
Mar 19, 2009·Endocrine Development·Ken H Darzy, Stephen M Shalet
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie L RobisonLonnie K Zeltzer
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy M LeisenringYutaka Yasui
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenLeslie L Robison
Dec 7, 2010·Radiation Research·Elaine Ron, Alina Brenner
Mar 30, 2011·International Journal of Cancer. Journal International Du Cancer·Georg BrabantMichael M Hawkins
Nov 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles Sklar, Suzanne Wolden
Jun 29, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Ken H Darzy
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wassim ChemaitillyCharles A Sklar
Aug 1, 2016·Current Treatment Options in Oncology·Cecilia Follin, Eva Marie Erfurth
Dec 22, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarah C ClementHanneke M van Santen
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Jay H LubinLene H S Veiga

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Citations

Oct 10, 2020·Journal of Neural Transmission·Christoph ReinersShunichi Yamashita
Oct 9, 2019·The Lancet. Diabetes & Endocrinology·Livia LamartinaDavid S Cooper
Apr 4, 2021·International Journal of Radiation Oncology, Biology, Physics·Michael T MilanoIvan R Vogelius
Aug 7, 2021·International Journal of Radiation Biology·Yeni Natalia C Perez-GelvezCarl W Bergmann
Dec 13, 2018·Hormone Research in Pædiatrics·Steven G Waguespack
Nov 6, 2021·Leukemia & Lymphoma·Aislinn Macklin-DohertyAnthony Swerdlow
Sep 22, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Christoph ReinersRita Schneider

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