Hypothyroidism associated with therapy for multi-drug-resistant tuberculosis in Australia

Internal Medicine Journal
Yee-Ming M CheungMathis Grossmann

Abstract

Reports from resource-poor countries have associated thionamide- and para-aminosalicylate sodium (PAS)-based treatment of multi-drug-resistant tuberculosis (MDR-TB) with the development of hypothyroidism. To identify predictors and assess the cumulative proportions of hypothyroidism in patients treated for MDR-TB with these agents in Australia. Retrospective multicentre study of MDR-TB patients from five academic centres covering tuberculosis (TB) services in Victoria, Australia. Patients were identified using each centre's pharmacy department and cross checked with the Victorian Tuberculosis Program. Hypothyroidism was categorised as subclinical if the thyroid-stimulating hormone was elevated and as overt if free thyroxine (fT4) was additionally reduced on two separate occasions. Our main outcome measured was the cumulative proportion of hypothyroidism (at 5 years from treatment initiation). Of the 29 cases available for analysis, the cumulative proportion of hypothyroidism at 5 years was 37% (95% confidence interval (CI): 0-57.8%). Eight of the nine affected cases developed hypothyroidism within the first 12 months of treatment. Hypothyroidism was marginally (P = 0.06) associated with higher prothionamide/PAS dosing and was r...Continue Reading

References

Mar 1, 1979·Clinics in Endocrinology and Metabolism·E H McLaren, W D Alexander
Apr 1, 1986·The Journal of Clinical Endocrinology and Metabolism·P S HamblinJ R Stockigt
Jun 1, 1984·Annals of Internal Medicine·D DruckerG N Burrow
Nov 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S A SoumakisH W Harris
Nov 1, 1953·The Journal of Endocrinology·J BEATTIE, R D CHAMBERS
Nov 6, 1954·Lancet·A G MACGREGOR, A R SOMNER
Nov 20, 1954·Lancet·D A EDWARDSW R TROTTER
Mar 5, 2005·The New England Journal of Medicine·David S Cooper
Jul 1, 2005·The New England Journal of Medicine·Marie E McDonnellJohn Bernardo
Jan 13, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·Bikram S DuttaAbhijeet Singh
Feb 14, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·H SattiK J Seung
Aug 9, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·J GuptaH J Milburn
Oct 10, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·Chawangwa Modongo, Nicola M Zetola
Apr 8, 2014·The Medical Journal of Australia·Joshua R FrancisJustin Waring
Jun 12, 2016·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·R BaresC Schmotzer
Sep 7, 2016·Journal of Tuberculosis Research·Somashekar MunivenkatappaPatrick K Moonan
Mar 24, 2017·The European Respiratory Journal·Dennis FalzonKarin Weyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.