PMID: 9543494May 16, 1998Paper

Hypothyroidism decreases the ATP sensitivity of KATP channels from rat heart

The Journal of Membrane Biology
P LightR J French

Abstract

The effects of thyroid status on the properties of ATP-sensitive potassium channels were investigated. Single-channel recordings were made using excised inside-out membrane patches from enzymatically dissociated ventricular myocytes from hearts of control and thyroidectomized rats and each group was studied with and without administration of thyroid hormone. In patches excised from hypothyroid myocytes the IC50 for ATP inhibition of KATP channels was 110 micro m. This value was 3-fold higher than the IC50 in control myocytes (43 micro m). Treatment of hypothyroid rats to restore physiological levels of thyroid hormone (tri-iodothyronine, T3), resulted in a return to normal ATP-sensitivity (IC50 = 46 micro M). In patches from animals rendered hyperthyroid, the IC50 for ATP was 50 micro M and this value was not significantly different from the control. There was no difference in the cooperativity of ATP-binding (Hill coefficient, nH) among control (nH = 2.2), hypothyroid (nH = 2.1), T3-treated (nH = 2.0) and hyperthyroid groups (nH = 2.4). The unitary conductance was unchanged and there was no apparent change in intraburst kinetics between examples of single KATP channels from control and hypothyroid rats. Action potentials recor...Continue Reading

Citations

Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni
Jan 30, 2002·British Journal of Pharmacology·Jocelyn E Manning FoxPeter E Light
Nov 21, 2001·Pharmacotherapy·M G Reichert, K C Verzino
May 1, 2013·Canadian Journal of Physiology and Pharmacology·Deepak NarangFrances Plane
Nov 24, 2012·Aging Cell·Li BaoWilliam A Coetzee
Sep 17, 2013·Circulation. Arrhythmia and Electrophysiology·Youhua ZhangA Martin Gerdes
Jul 2, 2015·PloS One·Aliashraf GodiniSaleh Zahediasl
Sep 16, 2006·The EMBO Journal·Michael J RiedelPeter E Light
Oct 10, 2013·British Journal of Pharmacology·Istvan BaczkoPeter E Light
Mar 19, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·István BaczkóPeter E Light
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P E LightR J French
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·Z Q SunI Klein
Oct 1, 1998·The American Journal of Physiology·Y ShimoniR J French

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