Hypothyroidism during antithyroid drug treatment with methimazole is a favorable prognostic indicator in patients with Graves' disease

Thyroid : Official Journal of the American Thyroid Association
Young Kwang ChooHyun-Kyung Chung

Abstract

A major problem with antithyroid drug (ATD) therapy in Graves' disease is the high relapse rate. Therefore, clinicians have sought prognostic indicators of permanent remission. Suppression of serum thyrotropin (TSH) when ATD therapy is stopped carries a poor prognosis, but little is known regarding the significance of elevated serum TSH concentrations in the course of ATD therapy. The objective of this study was to determine if elevated serum TSH concentrations during methimazole (MMI) therapy is associated with a favorable long-term prognosis. We retrospectively studied patients with Graves' disease who were initially on MMI, in whom this drug was stopped because they had undetectable thyroid-stimulating antibodies (TSAbs) or were euthyroid after at least 24 months on MMI treatment. A strategy of high MMI doses plus T4 was not used in these patients. We identified 40 patients with elevated serum TSH concentration (>10 microIU/mL) during MMI therapy (H-TSH group). Eighty-five percent of the H-TSH group had negative tests for TSAb. The H-TSH group was sex- and age-matched with 37 patients who had similar selection criteria, but did not have elevated serum TSH concentration during MMI therapy (N-TSH group). The H-TSH and N-TSH gr...Continue Reading

References

Jan 1, 1987·The New England Journal of Medicine·T H TöttermanI Mendel-Hartvig
Aug 7, 1980·The New England Journal of Medicine·A M McGregorR Hall
Sep 1, 1995·European Journal of Clinical Investigation·A TsatsoulisH M Moutsopoulos
Jun 16, 1994·The New England Journal of Medicine·J A Franklyn
Jun 1, 1997·Thyroid : Official Journal of the American Thyroid Association·P VittiA Pinchera
Mar 24, 1998·Thyroid : Official Journal of the American Thyroid Association·V MichelangeliP Colman
Mar 5, 2005·The New England Journal of Medicine·David S Cooper

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Citations

Sep 10, 2010·Thyroid : Official Journal of the American Thyroid Association·Kristien Boelaert
Dec 25, 2013·European Journal of Endocrinology·Eric MohlinMats Eliasson
Oct 27, 2016·European Journal of Endocrinology·Tristan StrujaPhilipp Schuetz
Dec 26, 2018·Journal of Veterinary Research·Marcin GołyńskiMarcin Szczepanik
Apr 17, 2019·Journal of Veterinary Research·Marcin GołyńskiPiotr Dobrowolski
Sep 20, 2012·Arquivos brasileiros de endocrinologia e metabologia·Renata Loureiro MorettoJoão Hamilton Romaldini

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