Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Jing DongJie Chen

Abstract

Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal neurogranin, calcium/calmodulin dependent protein kinase II (CaMKII), calmodulin (CaM) and calcineurin (CaN) are implicated in the brain impairment in lactational rat hippocampus following developmental ID and hypothyroidism. Three developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5 ppm or 15 ppm)-added drinking water from gestational day (GD) 6 till postnatal day (PN) 21. Then, the neurogranin, CaMKII, CaM and CaN in the hippocampus were detected with immunohistochemistry and western blotting on PN14 and PN21. The iodine-deficient and hypothyroid pups showed significantly lower level of neurogranin, CaMKII and CaM and significantly increased CaN in hippocampal CA1 and CA3 regions than the controls on PN14 and PN21 (P<0.05, respectively). Data indicate that, in lactational rats, hippocampal neurogranin, CaMKII, CaM and CaN are involved in the brain impairment by developmental ID and hypothyroidism.

References

Jan 1, 1996·Brain Research Bulletin·C FrançoisG Percheron
Mar 18, 2000·The Journal of Nutrition·B S Hetzel
Jun 13, 2002·Environmental Health Perspectives·Kembra L Howdeshell
Nov 19, 2003·Biochemical and Biophysical Research Communications·Isabelle M Mansuy
Dec 4, 2003·Thyroid : Official Journal of the American Thyroid Association·Grant W AndersonSidney A Jones
Mar 30, 2004·Brain Research. Molecular Brain Research·M HussonP Higueret
May 26, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Gabriella Morreale de EscobarFrancisco Escobar del Rey
Aug 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·M S KibirigeH T Delves
Nov 24, 2004·European Journal of Endocrinology·Gabriella Morreale de EscobarFrancisco Escobar del Rey
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kuo-Ping HuangDetlef Balschun
Feb 15, 2005·Neurobiology of Aging·Isabel G NewtonDavid R Riddle
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun XuJian Kang
Aug 23, 2005·Vitamins and Hormones·Juan Bernal
Sep 6, 2006·Experimental Neurology·K H Alzoubi, K A Alkadhi
Oct 27, 2007·Trends in Endocrinology and Metabolism : TEM·Pere BerbelGabriella Morreale de Escobar
Nov 7, 2007·Frontiers in Neuroendocrinology·Paul J DavisFaith B Davis
Jun 19, 2008·Environmental Health Perspectives·Mary E Gilbert, Li Sui
Mar 19, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Frank O JohnsonRussell L Carr
Feb 23, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Alida Melse-Boonstra, Nidhi Jaiswal

❮ Previous
Next ❯

Citations

Sep 4, 2014·Acta Physiologica Hungarica·Eman S H Abd AllahManal M Sayed
Aug 16, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Anna Milanesi, Gregory A Brent
Jun 3, 2021·Cancers·Gabriella SchieraItalia Di Liegro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.